Role of the Retinoblastoma protein, Rb, during adult neurogenesis in the olfactory bulb

Rayan Mohammad Mahmoud Naser, Renaud Vandenbosch, Saad Omais, Dayana Hayek, Carine Jaafar, Sawsan Al Lafi, Afaf Saliba, Maarouf Baghdadi, Larissa Skaf, Noel Ghanem

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Adult neural stem cells (aNSCs) are relatively quiescent populations that give rise to distinct neuronal subtypes throughout life, yet, at a very low rate and restricted differentiation potential. Thus, identifying the molecular mechanisms that control their cellular expansion is critical for regeneration after brain injury. Loss of the Retinoblastoma protein, Rb, leads to several defects in cell cycle as well as neuronal differentiation and migration during brain development. Here, we investigated the role of Rb during adult neurogenesis in the olfactory bulb (OB) by inducing its temporal deletion in aNSCs and progenitors. Loss of Rb was associated with increased proliferation of adult progenitors in the subventricular zone (SVZ) and the rostral migratory stream (RMS) but did not alter self-renewal of aNSCs or neuroblasts subsequent migration and terminal differentiation. Hence, one month after their birth, Rb-null neuroblasts were able to differentiate into distinct subtypes of GABAergic OB interneurons but were gradually lost after 3 months. Similarly, Rb controlled aNSCs/progenitors proliferation in vitro without affecting their differentiation capacity. This enhanced SVZ/OB neurogenesis associated with loss of Rb was only transient and negatively affected by increased apoptosis indicating a critical requirement for Rb in the long-term survival of adult-born OB interneurons.
Original languageEnglish (US)
Issue number1
StatePublished - Feb 5 2016
Externally publishedYes

ASJC Scopus subject areas

  • General


Dive into the research topics of 'Role of the Retinoblastoma protein, Rb, during adult neurogenesis in the olfactory bulb'. Together they form a unique fingerprint.

Cite this