Roles for noncoding RNAs in cell-fate determination and regeneration

Mo Li; Juan Carlos Izpisua Belmonte

doi:10.1038/nsmb.2946

Roles for noncoding RNAs in cell-fate determination and regeneration

Mo Li, Juan Carlos Izpisua Belmonte

Research output: Contribution to journal › Comment/debate › peer-review

22 Scopus citations

Abstract

Cellular fate is determined by transcriptional networks and epigenetic states. In addition to protein factors, noncoding RNAs (ncRNAs), particularly microRNAs and long ncRNAs, are able to remodel transcriptional circuits and reshape epigenetic landscapes. Here we draw upon recent findings to discuss the emerging roles of these ncRNAs in cellular reprogramming, transdifferentiation and organ regeneration.

Original language	English (US)
Pages (from-to)	2-4
Number of pages	3
Journal	Nature Structural and Molecular Biology
Volume	22
Issue number	1
DOIs	https://doi.org/10.1038/nsmb.2946
State	Published - Jan 1 2015
Externally published	Yes

ASJC Scopus subject areas

Structural Biology
Molecular Biology

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10.1038/nsmb.2946

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abstract = "Cellular fate is determined by transcriptional networks and epigenetic states. In addition to protein factors, noncoding RNAs (ncRNAs), particularly microRNAs and long ncRNAs, are able to remodel transcriptional circuits and reshape epigenetic landscapes. Here we draw upon recent findings to discuss the emerging roles of these ncRNAs in cellular reprogramming, transdifferentiation and organ regeneration.",

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AB - Cellular fate is determined by transcriptional networks and epigenetic states. In addition to protein factors, noncoding RNAs (ncRNAs), particularly microRNAs and long ncRNAs, are able to remodel transcriptional circuits and reshape epigenetic landscapes. Here we draw upon recent findings to discuss the emerging roles of these ncRNAs in cellular reprogramming, transdifferentiation and organ regeneration.

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M3 - Comment/debate

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AN - SCOPUS:84925282893

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EP - 4

JO - Nature Structural and Molecular Biology

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Roles for noncoding RNAs in cell-fate determination and regeneration

Abstract

ASJC Scopus subject areas

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