Room-temperature base-free copper-catalyzed trifluoromethylation of organotrifluoroborates to trifluoromethylarenes

Yuanyuan Huang; Xin Fang; Xiaoxi Lin; Huaifeng Li; Weiming He; Kuo-Wei Huang; Yaofeng Yuan; Zhiqiang Weng

doi:10.1016/j.tet.2012.09.083

Room-temperature base-free copper-catalyzed trifluoromethylation of organotrifluoroborates to trifluoromethylarenes

Yuanyuan Huang, Xin Fang, Xiaoxi Lin, Huaifeng Li, Weiming He, Kuo-Wei Huang, Yaofeng Yuan, Zhiqiang Weng

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

An efficient room temperature copper-catalyzed trifluoromethylation of organotrifluoroborates under the base free condition using an electrophilic trifluoromethylating reagent is demonstrated. The corresponding trifluoromethylarenes were obtained in good to excellent yields and the reaction tolerates a wide range of functional groups. © 2012 Elsevier Ltd. All rights reserved.

Original language	English (US)
Pages (from-to)	9949-9953
Number of pages	5
Journal	Tetrahedron
Volume	68
Issue number	48
DOIs	https://doi.org/10.1016/j.tet.2012.09.083
State	Published - Dec 2012

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Drug Discovery

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10.1016/j.tet.2012.09.083

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title = "Room-temperature base-free copper-catalyzed trifluoromethylation of organotrifluoroborates to trifluoromethylarenes",

abstract = "An efficient room temperature copper-catalyzed trifluoromethylation of organotrifluoroborates under the base free condition using an electrophilic trifluoromethylating reagent is demonstrated. The corresponding trifluoromethylarenes were obtained in good to excellent yields and the reaction tolerates a wide range of functional groups. {\textcopyright} 2012 Elsevier Ltd. All rights reserved.",

author = "Yuanyuan Huang and Xin Fang and Xiaoxi Lin and Huaifeng Li and Weiming He and Kuo-Wei Huang and Yaofeng Yuan and Zhiqiang Weng",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: We acknowledge the financial support from National Natural Science Foundation of China (21072030) and Fuzhou University (022318) to Z.W. and King Abdullah University of Science and Technology to K.-W.H.",

year = "2012",

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doi = "10.1016/j.tet.2012.09.083",

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T1 - Room-temperature base-free copper-catalyzed trifluoromethylation of organotrifluoroborates to trifluoromethylarenes

AU - Huang, Yuanyuan

AU - Fang, Xin

AU - Lin, Xiaoxi

AU - Li, Huaifeng

AU - He, Weiming

AU - Huang, Kuo-Wei

AU - Yuan, Yaofeng

AU - Weng, Zhiqiang

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: We acknowledge the financial support from National Natural Science Foundation of China (21072030) and Fuzhou University (022318) to Z.W. and King Abdullah University of Science and Technology to K.-W.H.

PY - 2012/12

Y1 - 2012/12

N2 - An efficient room temperature copper-catalyzed trifluoromethylation of organotrifluoroborates under the base free condition using an electrophilic trifluoromethylating reagent is demonstrated. The corresponding trifluoromethylarenes were obtained in good to excellent yields and the reaction tolerates a wide range of functional groups. © 2012 Elsevier Ltd. All rights reserved.

AB - An efficient room temperature copper-catalyzed trifluoromethylation of organotrifluoroborates under the base free condition using an electrophilic trifluoromethylating reagent is demonstrated. The corresponding trifluoromethylarenes were obtained in good to excellent yields and the reaction tolerates a wide range of functional groups. © 2012 Elsevier Ltd. All rights reserved.

UR - http://hdl.handle.net/10754/562437

UR - https://linkinghub.elsevier.com/retrieve/pii/S0040402012014731

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DO - 10.1016/j.tet.2012.09.083

M3 - Article

SN - 0040-4020

VL - 68

SP - 9949

EP - 9953

JO - Tetrahedron

JF - Tetrahedron

IS - 48

ER -

Room-temperature base-free copper-catalyzed trifluoromethylation of organotrifluoroborates to trifluoromethylarenes

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