Search for the evolutionary origin of a brain: Planarian brain characterized by microarray

Masumi Nakazawa; Francesc Cebrià; Katsuhiko Mineta; Kazuho Ikeo; Kiyokazu Agata; Takashi Gojobori

doi:10.1093/molbev/msg086

Search for the evolutionary origin of a brain: Planarian brain characterized by microarray

Masumi Nakazawa, Francesc Cebrià, Katsuhiko Mineta, Kazuho Ikeo, Kiyokazu Agata, Takashi Gojobori^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abstract

The origin of the brain remains a challenging problem in evolutionary studies. To understand when and how the structural brain emerged, we analyzed the central nervous system (CNS) of a lower invertebrate, planarian. We conducted a large-scale screening of the head part - specific genes in the planarian by constructing a cDNA microarray. Competitive hybridization of cDNAs between a head portion and the other body portion of planarians revealed 205 genes with head part - specific spikes, including essential genes in the vertebrate nervous system. The expression patterns of the top 30 genes showing the strongest spikes implied that the planarian brain has undergone functional regionalization. We demonstrate the complex cytoarchitecture of the planarian brain, despite its simple superficiality of the morphology.

Original language	English (US)
Pages (from-to)	784-791
Number of pages	8
Journal	MOLECULAR BIOLOGY AND EVOLUTION
Volume	20
Issue number	5
DOIs	https://doi.org/10.1093/molbev/msg086
State	Published - May 1 2003
Externally published	Yes

Keywords

Central nervous system
Microarray
Origin of brain
Planarian

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
Molecular Biology
Genetics

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10.1093/molbev/msg086

Cite this

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Search for the evolutionary origin of a brain: Planarian brain characterized by microarray

Abstract

Keywords

ASJC Scopus subject areas

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