Searching for specificity in SH domains

John E. Ladbury; Stefan Arold

doi:10.1016/S1074-5521(00)00067-3

Searching for specificity in SH domains

John E. Ladbury^*, Stefan Arold

^*Corresponding author for this work

Research output: Contribution to journal › Comment/debate › peer-review

93 Scopus citations

Abstract

Elucidating protein-protein interactions has been a central feature to understanding intracellular signal transduction. Many of the binding sites of the interacting proteins in these pathways are within highly sequentially homologous and structurally conserved domains. We challenge the dogma that mutual exclusivity in signalling is derived from a high level of specificity in these domains.

Original language	English (US)
Pages (from-to)	R3-R8
Journal	Chemistry and Biology
Volume	7
Issue number	1
DOIs	https://doi.org/10.1016/S1074-5521(00)00067-3
State	Published - Jan 1 2000
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmacology
Drug Discovery
Clinical Biochemistry

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10.1016/S1074-5521(00)00067-3

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title = "Searching for specificity in SH domains",

abstract = "Elucidating protein-protein interactions has been a central feature to understanding intracellular signal transduction. Many of the binding sites of the interacting proteins in these pathways are within highly sequentially homologous and structurally conserved domains. We challenge the dogma that mutual exclusivity in signalling is derived from a high level of specificity in these domains.",

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AB - Elucidating protein-protein interactions has been a central feature to understanding intracellular signal transduction. Many of the binding sites of the interacting proteins in these pathways are within highly sequentially homologous and structurally conserved domains. We challenge the dogma that mutual exclusivity in signalling is derived from a high level of specificity in these domains.

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DO - 10.1016/S1074-5521(00)00067-3

M3 - Comment/debate

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Searching for specificity in SH domains

Abstract

ASJC Scopus subject areas

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