Searching for specificity in SH domains

John E. Ladbury*, Stefan Arold

*Corresponding author for this work

Research output: Contribution to journalComment/debatepeer-review

92 Scopus citations


Elucidating protein-protein interactions has been a central feature to understanding intracellular signal transduction. Many of the binding sites of the interacting proteins in these pathways are within highly sequentially homologous and structurally conserved domains. We challenge the dogma that mutual exclusivity in signalling is derived from a high level of specificity in these domains.

Original languageEnglish (US)
Pages (from-to)R3-R8
JournalChemistry and Biology
Issue number1
StatePublished - Jan 1 2000
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry


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