Selective import of biomolecules through nanopored silicon nitride membranes

Manola Moretti; Enzo Di Fabrizio; Francesco De Angelis; Giuseppe Firrao

doi:10.1109/ULIS.2008.4527138

Selective import of biomolecules through nanopored silicon nitride membranes

Manola Moretti^*, Enzo Di Fabrizio, Francesco De Angelis, Giuseppe Firrao

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Selective transport of molecules through membrane is a prerogative of biological systems that is still far from being matched by nanoscale human manufacturing. Here we report our attempt to define a system based on pored silicon nitride membranes and mobile transporters for the selective recognition and import of nanosized objects (proteins, quantum dots, latex particles) from an external compartment. The system uses paramagnetic beads, modified to recognize specific target molecules, which are delivered to arrays of precisely milled pores. After capture of their target, the loaded transporters are removed from the pore and replaced. Prototypes that make use of electrophoretic or electromagnetic forces to mobilize the beads have been constructed and evaluated.

Original language	English (US)
Title of host publication	ULIS 2008 - 9th International Conference on ULtimate Integration of Silicon
Pages	49-52
Number of pages	4
DOIs	https://doi.org/10.1109/ULIS.2008.4527138
State	Published - 2008
Externally published	Yes
Event	9th International Conference on ULtimate Integration of Silicon, ULIS 2008 - Duration: Mar 13 2008 → Mar 14 2008

Publication series

Name	ULIS 2008 - 9th International Conference on ULtimate Integration of Silicon

Other

Other	9th International Conference on ULtimate Integration of Silicon, ULIS 2008
Period	03/13/08 → 03/14/08

ASJC Scopus subject areas

Electrical and Electronic Engineering

Access to Document

10.1109/ULIS.2008.4527138

Cite this

Moretti, M., Di Fabrizio, E., De Angelis, F., & Firrao, G. (2008). Selective import of biomolecules through nanopored silicon nitride membranes. In ULIS 2008 - 9th International Conference on ULtimate Integration of Silicon (pp. 49-52). Article 4527138 (ULIS 2008 - 9th International Conference on ULtimate Integration of Silicon). https://doi.org/10.1109/ULIS.2008.4527138

@inproceedings{b8c321e2c32c44adbc6c383e8896acbe,

title = "Selective import of biomolecules through nanopored silicon nitride membranes",

abstract = "Selective transport of molecules through membrane is a prerogative of biological systems that is still far from being matched by nanoscale human manufacturing. Here we report our attempt to define a system based on pored silicon nitride membranes and mobile transporters for the selective recognition and import of nanosized objects (proteins, quantum dots, latex particles) from an external compartment. The system uses paramagnetic beads, modified to recognize specific target molecules, which are delivered to arrays of precisely milled pores. After capture of their target, the loaded transporters are removed from the pore and replaced. Prototypes that make use of electrophoretic or electromagnetic forces to mobilize the beads have been constructed and evaluated.",

author = "Manola Moretti and {Di Fabrizio}, Enzo and {De Angelis}, Francesco and Giuseppe Firrao",

year = "2008",

doi = "10.1109/ULIS.2008.4527138",

language = "English (US)",

isbn = "9781424417308",

series = "ULIS 2008 - 9th International Conference on ULtimate Integration of Silicon",

pages = "49--52",

booktitle = "ULIS 2008 - 9th International Conference on ULtimate Integration of Silicon",

note = "9th International Conference on ULtimate Integration of Silicon, ULIS 2008 ; Conference date: 13-03-2008 Through 14-03-2008",

}

Moretti, M, Di Fabrizio, E, De Angelis, F & Firrao, G 2008, Selective import of biomolecules through nanopored silicon nitride membranes. in ULIS 2008 - 9th International Conference on ULtimate Integration of Silicon., 4527138, ULIS 2008 - 9th International Conference on ULtimate Integration of Silicon, pp. 49-52, 9th International Conference on ULtimate Integration of Silicon, ULIS 2008, 03/13/08. https://doi.org/10.1109/ULIS.2008.4527138

Selective import of biomolecules through nanopored silicon nitride membranes. / Moretti, Manola; Di Fabrizio, Enzo; De Angelis, Francesco et al.
ULIS 2008 - 9th International Conference on ULtimate Integration of Silicon. 2008. p. 49-52 4527138 (ULIS 2008 - 9th International Conference on ULtimate Integration of Silicon).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Selective import of biomolecules through nanopored silicon nitride membranes

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AU - Di Fabrizio, Enzo

AU - De Angelis, Francesco

AU - Firrao, Giuseppe

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N2 - Selective transport of molecules through membrane is a prerogative of biological systems that is still far from being matched by nanoscale human manufacturing. Here we report our attempt to define a system based on pored silicon nitride membranes and mobile transporters for the selective recognition and import of nanosized objects (proteins, quantum dots, latex particles) from an external compartment. The system uses paramagnetic beads, modified to recognize specific target molecules, which are delivered to arrays of precisely milled pores. After capture of their target, the loaded transporters are removed from the pore and replaced. Prototypes that make use of electrophoretic or electromagnetic forces to mobilize the beads have been constructed and evaluated.

AB - Selective transport of molecules through membrane is a prerogative of biological systems that is still far from being matched by nanoscale human manufacturing. Here we report our attempt to define a system based on pored silicon nitride membranes and mobile transporters for the selective recognition and import of nanosized objects (proteins, quantum dots, latex particles) from an external compartment. The system uses paramagnetic beads, modified to recognize specific target molecules, which are delivered to arrays of precisely milled pores. After capture of their target, the loaded transporters are removed from the pore and replaced. Prototypes that make use of electrophoretic or electromagnetic forces to mobilize the beads have been constructed and evaluated.

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DO - 10.1109/ULIS.2008.4527138

M3 - Conference contribution

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SN - 9781424417308

T3 - ULIS 2008 - 9th International Conference on ULtimate Integration of Silicon

SP - 49

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BT - ULIS 2008 - 9th International Conference on ULtimate Integration of Silicon

T2 - 9th International Conference on ULtimate Integration of Silicon, ULIS 2008

Y2 - 13 March 2008 through 14 March 2008

ER -

Selective import of biomolecules through nanopored silicon nitride membranes

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Other

ASJC Scopus subject areas

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