TY - JOUR
T1 - Selective on site separation and detection of molecules in diluted solutions with super-hydrophobic clusters of plasmonic nanoparticles
AU - Gentile, Francesco T.
AU - Coluccio, Maria Laura
AU - Proietti Zaccaria, Remo
AU - Francardi, Marco
AU - Cojoc, Gheorghe
AU - Perozziello, Gerardo
AU - Raimondo, Raffaella
AU - Candeloro, Patrizio
AU - Di Fabrizio, Enzo M.
N1 - KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: This work has been partially funded by the EU Commission, the European Social Fund and the Calabria Region (POR Calabria FSE 2007-2013), from the Italian Minister of Health under the project "Cancer biomarker detection using micro-structured/super-hydrophobic surfaces and advanced spectroscopy techniques" (Project no. GR-2010-2320665), and the project "High throughput analysis of cancer cells for therapy evaluation by microfluidic platforms integrating plasmonic nanodevices" (Project no. GR-2010-2311677), and from the Cariplo Foundation under the project "New Frontiers in Plasmonic Nano-sensing" (Grant no. 2011-0338).
PY - 2014
Y1 - 2014
N2 - Super-hydrophobic surfaces are bio-inspired interfaces with a superficial texture that, in its most common evolution, is formed by a periodic lattice of silicon micro-pillars. Similar surfaces reveal superior properties compared to conventional flat surfaces, including very low friction coefficients. In this work, we modified meso-porous silicon micro-pillars to incorporate networks of metal nano-particles into the porous matrix. In doing so, we obtained a multifunctional-hierarchical system in which (i) at a larger micrometric scale, the super-hydrophobic pillars bring the molecules dissolved in an ultralow-concentration droplet to the active sites of the device, (ii) at an intermediate meso-scale, the meso-porous silicon film adsorbs the low molecular weight content of the solution and, (iii) at a smaller nanometric scale, the aggregates of silver nano-particles would measure the target molecules with unprecedented sensitivity. In the results, we demonstrated how this scheme can be utilized to isolate and detect small molecules in a diluted solution in very low abundance ranges. The presented platform, coupled to Raman or other spectroscopy techniques, is a realistic candidate for the protein expression profiling of biological fluids. © 2014 the Partner Organisations.
AB - Super-hydrophobic surfaces are bio-inspired interfaces with a superficial texture that, in its most common evolution, is formed by a periodic lattice of silicon micro-pillars. Similar surfaces reveal superior properties compared to conventional flat surfaces, including very low friction coefficients. In this work, we modified meso-porous silicon micro-pillars to incorporate networks of metal nano-particles into the porous matrix. In doing so, we obtained a multifunctional-hierarchical system in which (i) at a larger micrometric scale, the super-hydrophobic pillars bring the molecules dissolved in an ultralow-concentration droplet to the active sites of the device, (ii) at an intermediate meso-scale, the meso-porous silicon film adsorbs the low molecular weight content of the solution and, (iii) at a smaller nanometric scale, the aggregates of silver nano-particles would measure the target molecules with unprecedented sensitivity. In the results, we demonstrated how this scheme can be utilized to isolate and detect small molecules in a diluted solution in very low abundance ranges. The presented platform, coupled to Raman or other spectroscopy techniques, is a realistic candidate for the protein expression profiling of biological fluids. © 2014 the Partner Organisations.
UR - http://hdl.handle.net/10754/563217
UR - http://xlink.rsc.org/?DOI=C4NR00796D
UR - http://www.scopus.com/inward/record.url?scp=84903554520&partnerID=8YFLogxK
U2 - 10.1039/c4nr00796d
DO - 10.1039/c4nr00796d
M3 - Article
SN - 2040-3364
VL - 6
SP - 8208
EP - 8225
JO - Nanoscale
JF - Nanoscale
IS - 14
ER -