TY - JOUR
T1 - Self-Assembly of Highly Stable Zirconium(IV) Coordination Cages with Aggregation Induced Emission Molecular Rotors for Live-Cell Imaging.
AU - Dong, Jinqiao
AU - Pan, Yutong
AU - Wang, Heng
AU - Yang, Kuiwei
AU - Liu, Lingmei
AU - Qiao, Zhiwei
AU - Di Yuan, Yi
AU - Peh, Shing Bo
AU - Zhang, Jian
AU - Shi, Leilei
AU - Liang, Hong
AU - Han, Yu
AU - Li, Xiaopeng
AU - Jiang, Jianwen
AU - Liu, Bin
AU - Zhao, Dan
N1 - KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: This work was supported by the National Research Founda-tion Singapore (NRF2018-NRF-ANR007 POCEMON), theMinistry of Education—Singapore (MOE AcRF Tier 1 R-279-000-540-114, R-279-000-482-133, Tier 2 MOE2018-T2-2-148), the Agency for Science, Technology and Research (IRGA1783c0015, IAF-PP A1789a0024), National Natural ScienceFoundation of China (No. 21676094 and 21576058), Funda-mental Research Funds for the Central Universities(2017MS083), and the technical support from NationalSupercomputer Center in Guangzhou (Tianhe-2).
PY - 2020/1/23
Y1 - 2020/1/23
N2 - The self-assembly of highly stable zirconium(IV)-based coordination cages with aggregation induced emission (AIE) molecular rotors for in vitro bio-imaging is reported. The two coordination cages, NUS-100 and NUS-101, are assembled from the highly stable trinuclear zirconium vertices and two flexible carboxyl-decorated tetraphenylethylene (TPE) spacers. Extensive experimental and theoretical results show that the emissive intensity of the coordination cages can be controlled by restricting the dynamics of AIE-active molecular rotors though multiple external stimuli. Because the two coordination cages have excellent chemical stability in aqueous solutions (pH stability: 2-10) and impressive AIE characteristics contributed by the molecular rotors, they can be employed as novel biological fluorescent probes for in vitro live-cell imaging.
AB - The self-assembly of highly stable zirconium(IV)-based coordination cages with aggregation induced emission (AIE) molecular rotors for in vitro bio-imaging is reported. The two coordination cages, NUS-100 and NUS-101, are assembled from the highly stable trinuclear zirconium vertices and two flexible carboxyl-decorated tetraphenylethylene (TPE) spacers. Extensive experimental and theoretical results show that the emissive intensity of the coordination cages can be controlled by restricting the dynamics of AIE-active molecular rotors though multiple external stimuli. Because the two coordination cages have excellent chemical stability in aqueous solutions (pH stability: 2-10) and impressive AIE characteristics contributed by the molecular rotors, they can be employed as novel biological fluorescent probes for in vitro live-cell imaging.
UR - http://hdl.handle.net/10754/661343
UR - http://doi.wiley.com/10.1002/anie.201915199
UR - http://www.scopus.com/inward/record.url?scp=85078665289&partnerID=8YFLogxK
U2 - 10.1002/anie.201915199
DO - 10.1002/anie.201915199
M3 - Article
C2 - 31859381
SN - 1433-7851
JO - Angewandte Chemie (International ed. in English)
JF - Angewandte Chemie (International ed. in English)
ER -