TY - JOUR
T1 - Sequential transfer of left-right information during vertebrate embryo development
AU - Raya, Ángel
AU - Belmonte, Juan Carlos Izpisúa
N1 - Funding Information:
The authors are indebted to all the members of the laboratory for fruitful discussions, and to May-Fun Schwarz for help in the preparation of this manuscript. The research on left-right asymmetry in our laboratory is supported by the NIH, American Heart Association, and G. Harold and Leila Y. Mathers Charitable Foundation.
PY - 2004/10
Y1 - 2004/10
N2 - The establishment of left-right asymmetries in the vertebrate embryo is carried out by complex genetic interactions that impart left- or right-sided information to the developing organs and structures. The origin of LR information is still unclear, but recent advances have provided new insights as to how it is relayed to the embryo node, and thereafter to the lateral plate mesoderm. In both steps, signaling by members of the transforming growth factor-β superfamily plays critical roles in amplifying and spreading LR cues, which are reviewed here.
AB - The establishment of left-right asymmetries in the vertebrate embryo is carried out by complex genetic interactions that impart left- or right-sided information to the developing organs and structures. The origin of LR information is still unclear, but recent advances have provided new insights as to how it is relayed to the embryo node, and thereafter to the lateral plate mesoderm. In both steps, signaling by members of the transforming growth factor-β superfamily plays critical roles in amplifying and spreading LR cues, which are reviewed here.
UR - http://www.scopus.com/inward/record.url?scp=5444229981&partnerID=8YFLogxK
U2 - 10.1016/j.gde.2004.07.011
DO - 10.1016/j.gde.2004.07.011
M3 - Review article
C2 - 15380250
AN - SCOPUS:5444229981
SN - 0959-437X
VL - 14
SP - 575
EP - 581
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
IS - 5
ER -