TY - JOUR
T1 - Serum Interleukin-8, Osteopontin, and Monocyte Chemoattractant Protein 1 Are Associated With Hepatic Fibrosis in Patients With Nonalcoholic Fatty Liver Disease
AU - Glass, Oliver
AU - Henao, Ricardo
AU - Patel, Keyur
AU - Guy, Cynthia D.
AU - Gruss, Hans J.
AU - Syn, Wing Kin
AU - Moylan, Cynthia A.
AU - Streilein, Robert
AU - Hall, Russell
AU - Mae Diehl, Anna
AU - Abdelmalek, Manal F.
N1 - Generated from Scopus record by KAUST IRTS on 2023-02-15
PY - 2018/11/1
Y1 - 2018/11/1
N2 - The severity of hepatic fibrosis is the primary predictor of liver-related morbidity and mortality in patients with nonalcoholic fatty liver disease (NAFLD). Unfortunately, noninvasive serum biomarkers for NAFLD-associated fibrosis are limited. We analyzed baseline serum samples for 24 cytokines of 97 patients with biopsy-proven NAFLD. These patients were prospectively enrolled in a clinical study (ClinicalTrials.gov NCT00794716) to identify cytokines associated with liver fibrosis in patients with nonalcoholic steatohepatitis. Patients were stratified according to severity of hepatic fibrosis (mild, stage 0-1, n = 37; moderate, stage 2, n = 40; and advanced, stage 3-4, n = 20) while controlling for age, race, sex, body mass index, and diabetes mellitus. Interleukin-8 (IL-8), osteopontin (OPN), and monocyte chemoattractant protein 1 (MCP1) were associated with liver fibrosis (P
AB - The severity of hepatic fibrosis is the primary predictor of liver-related morbidity and mortality in patients with nonalcoholic fatty liver disease (NAFLD). Unfortunately, noninvasive serum biomarkers for NAFLD-associated fibrosis are limited. We analyzed baseline serum samples for 24 cytokines of 97 patients with biopsy-proven NAFLD. These patients were prospectively enrolled in a clinical study (ClinicalTrials.gov NCT00794716) to identify cytokines associated with liver fibrosis in patients with nonalcoholic steatohepatitis. Patients were stratified according to severity of hepatic fibrosis (mild, stage 0-1, n = 37; moderate, stage 2, n = 40; and advanced, stage 3-4, n = 20) while controlling for age, race, sex, body mass index, and diabetes mellitus. Interleukin-8 (IL-8), osteopontin (OPN), and monocyte chemoattractant protein 1 (MCP1) were associated with liver fibrosis (P
UR - https://onlinelibrary.wiley.com/doi/10.1002/hep4.1237
UR - http://www.scopus.com/inward/record.url?scp=85062962139&partnerID=8YFLogxK
U2 - 10.1002/hep4.1237
DO - 10.1002/hep4.1237
M3 - Article
SN - 2471-254X
VL - 2
SP - 1344
EP - 1355
JO - Hepatology Communications
JF - Hepatology Communications
IS - 11
ER -
