Sesquiterpenes from the Saudi Arabian Red Sea sponge Lamellodysidea herbacea

Mohamed A. Tammam; Leto Aikaterini Tziveleka; Carlos M. Duarte; Efstathia Ioannou; Vassilios Roussis

doi:10.1016/j.phytol.2025.102969

Sesquiterpenes from the Saudi Arabian Red Sea sponge Lamellodysidea herbacea

Mohamed A. Tammam, Leto Aikaterini Tziveleka, Carlos M. Duarte, Efstathia Ioannou, Vassilios Roussis^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Eleven sesquiterpenes (1–11), with the majority of them decorated with either a furan or a γ-lactone moiety in their carbocycle, were isolated from an organic extract of the marine sponge Lamellodysidea herbacea collected from the coral reefs in the vicinity of Thuwal in Saudi Arabia. Two of the isolated metabolites (1 and 2) are not previously described, whereas the linear furanosesquiterpene 11 is reported for the first time from a natural source. The structures and the relative configurations of the isolated metabolites have been determined through extensive analysis of their NMR and MS data. Compounds 1–11 were evaluated for their antibacterial and antioxidant activity but did not display any noteworthy activity.

Original language	English (US)
Article number	102969
Journal	Phytochemistry Letters
Volume	67
DOIs	https://doi.org/10.1016/j.phytol.2025.102969
State	Published - Jun 2025

Keywords

Dysideidae
Lamellodysidea herbacea
Red Sea
Saudi Arabia
Sesquiterpenes
Sponge

ASJC Scopus subject areas

Biotechnology
Biochemistry
Agronomy and Crop Science
Plant Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.phytol.2025.102969

Cite this

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title = "Sesquiterpenes from the Saudi Arabian Red Sea sponge Lamellodysidea herbacea",

abstract = "Eleven sesquiterpenes (1–11), with the majority of them decorated with either a furan or a γ-lactone moiety in their carbocycle, were isolated from an organic extract of the marine sponge Lamellodysidea herbacea collected from the coral reefs in the vicinity of Thuwal in Saudi Arabia. Two of the isolated metabolites (1 and 2) are not previously described, whereas the linear furanosesquiterpene 11 is reported for the first time from a natural source. The structures and the relative configurations of the isolated metabolites have been determined through extensive analysis of their NMR and MS data. Compounds 1–11 were evaluated for their antibacterial and antioxidant activity but did not display any noteworthy activity.",

keywords = "Dysideidae, Lamellodysidea herbacea, Red Sea, Saudi Arabia, Sesquiterpenes, Sponge",

author = "Tammam, \{Mohamed A.\} and Tziveleka, \{Leto Aikaterini\} and Duarte, \{Carlos M.\} and Efstathia Ioannou and Vassilios Roussis",

note = "Publisher Copyright: {\textcopyright} 2025 Phytochemical Society of Europe",

year = "2025",

month = jun,

doi = "10.1016/j.phytol.2025.102969",

language = "English (US)",

volume = "67",

journal = "Phytochemistry Letters",

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T1 - Sesquiterpenes from the Saudi Arabian Red Sea sponge Lamellodysidea herbacea

AU - Tammam, Mohamed A.

AU - Tziveleka, Leto Aikaterini

AU - Duarte, Carlos M.

AU - Ioannou, Efstathia

AU - Roussis, Vassilios

PY - 2025/6

Y1 - 2025/6

N2 - Eleven sesquiterpenes (1–11), with the majority of them decorated with either a furan or a γ-lactone moiety in their carbocycle, were isolated from an organic extract of the marine sponge Lamellodysidea herbacea collected from the coral reefs in the vicinity of Thuwal in Saudi Arabia. Two of the isolated metabolites (1 and 2) are not previously described, whereas the linear furanosesquiterpene 11 is reported for the first time from a natural source. The structures and the relative configurations of the isolated metabolites have been determined through extensive analysis of their NMR and MS data. Compounds 1–11 were evaluated for their antibacterial and antioxidant activity but did not display any noteworthy activity.

AB - Eleven sesquiterpenes (1–11), with the majority of them decorated with either a furan or a γ-lactone moiety in their carbocycle, were isolated from an organic extract of the marine sponge Lamellodysidea herbacea collected from the coral reefs in the vicinity of Thuwal in Saudi Arabia. Two of the isolated metabolites (1 and 2) are not previously described, whereas the linear furanosesquiterpene 11 is reported for the first time from a natural source. The structures and the relative configurations of the isolated metabolites have been determined through extensive analysis of their NMR and MS data. Compounds 1–11 were evaluated for their antibacterial and antioxidant activity but did not display any noteworthy activity.

KW - Dysideidae

KW - Lamellodysidea herbacea

KW - Red Sea

KW - Saudi Arabia

KW - Sesquiterpenes

KW - Sponge

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U2 - 10.1016/j.phytol.2025.102969

DO - 10.1016/j.phytol.2025.102969

M3 - Article

AN - SCOPUS:105003938882

SN - 1874-3900

VL - 67

JO - Phytochemistry Letters

JF - Phytochemistry Letters

M1 - 102969

ER -

Sesquiterpenes from the Saudi Arabian Red Sea sponge Lamellodysidea herbacea

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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