Single-atom nanozymes for electrochemical sensing oxidative stress biomarkers

Veerappan Mani; Guillermo Tostado-Blazquez; Vinoth Ramalingam; Khaled Nabil Salama

doi:10.1016/j.trechm.2025.04.008

Single-atom nanozymes for electrochemical sensing oxidative stress biomarkers

Veerappan Mani^*, Guillermo Tostado-Blazquez, Vinoth Ramalingam, Khaled Nabil Salama

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Developing reliable and low-cost sensors for oxidative stress biomarkers has gained significant interest for understanding and managing chronic diseases. Recently, single-atom nanozymes (SANs) with atomically dispersed metal sites and unique metal–nitrogen–carbon (M–N–C) structures have emerged as promising redox enzyme mimetics, offering superior catalytic efficiency and specificity, and with exceptional sensing capabilities for oxidative stress biomarkers such as hydrogen peroxide (H₂O₂₎, nitric oxide (NO), glutathione (GSH), and uric acid (UA). This review discusses key progress, challenges, and future directions in SANs for electrochemical determination of oxidative stress biomarkers, aiming to guide future research toward practical and impactful solutions in healthcare and disease management.

Original language	English (US)
Journal	Trends in Chemistry
DOIs	https://doi.org/10.1016/j.trechm.2025.04.008
State	Accepted/In press - 2025

Keywords

2D materials
biosensors
oxidative stress markers
sensors
single-atom catalysts

ASJC Scopus subject areas

General Chemistry

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10.1016/j.trechm.2025.04.008

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title = "Single-atom nanozymes for electrochemical sensing oxidative stress biomarkers",

abstract = "Developing reliable and low-cost sensors for oxidative stress biomarkers has gained significant interest for understanding and managing chronic diseases. Recently, single-atom nanozymes (SANs) with atomically dispersed metal sites and unique metal–nitrogen–carbon (M–N–C) structures have emerged as promising redox enzyme mimetics, offering superior catalytic efficiency and specificity, and with exceptional sensing capabilities for oxidative stress biomarkers such as hydrogen peroxide (H2O2), nitric oxide (NO), glutathione (GSH), and uric acid (UA). This review discusses key progress, challenges, and future directions in SANs for electrochemical determination of oxidative stress biomarkers, aiming to guide future research toward practical and impactful solutions in healthcare and disease management.",

keywords = "2D materials, biosensors, oxidative stress markers, sensors, single-atom catalysts",

author = "Veerappan Mani and Guillermo Tostado-Blazquez and Vinoth Ramalingam and Salama, \{Khaled Nabil\}",

note = "Publisher Copyright: {\textcopyright} 2025 Elsevier Inc.",

year = "2025",

doi = "10.1016/j.trechm.2025.04.008",

language = "English (US)",

journal = "Trends in Chemistry",

issn = "2589-5974",

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T1 - Single-atom nanozymes for electrochemical sensing oxidative stress biomarkers

AU - Mani, Veerappan

AU - Tostado-Blazquez, Guillermo

AU - Ramalingam, Vinoth

AU - Salama, Khaled Nabil

PY - 2025

Y1 - 2025

N2 - Developing reliable and low-cost sensors for oxidative stress biomarkers has gained significant interest for understanding and managing chronic diseases. Recently, single-atom nanozymes (SANs) with atomically dispersed metal sites and unique metal–nitrogen–carbon (M–N–C) structures have emerged as promising redox enzyme mimetics, offering superior catalytic efficiency and specificity, and with exceptional sensing capabilities for oxidative stress biomarkers such as hydrogen peroxide (H2O2), nitric oxide (NO), glutathione (GSH), and uric acid (UA). This review discusses key progress, challenges, and future directions in SANs for electrochemical determination of oxidative stress biomarkers, aiming to guide future research toward practical and impactful solutions in healthcare and disease management.

AB - Developing reliable and low-cost sensors for oxidative stress biomarkers has gained significant interest for understanding and managing chronic diseases. Recently, single-atom nanozymes (SANs) with atomically dispersed metal sites and unique metal–nitrogen–carbon (M–N–C) structures have emerged as promising redox enzyme mimetics, offering superior catalytic efficiency and specificity, and with exceptional sensing capabilities for oxidative stress biomarkers such as hydrogen peroxide (H2O2), nitric oxide (NO), glutathione (GSH), and uric acid (UA). This review discusses key progress, challenges, and future directions in SANs for electrochemical determination of oxidative stress biomarkers, aiming to guide future research toward practical and impactful solutions in healthcare and disease management.

KW - 2D materials

KW - biosensors

KW - oxidative stress markers

KW - sensors

KW - single-atom catalysts

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U2 - 10.1016/j.trechm.2025.04.008

DO - 10.1016/j.trechm.2025.04.008

M3 - Review article

AN - SCOPUS:105005643980

SN - 2589-5974

JO - Trends in Chemistry

JF - Trends in Chemistry

ER -

Single-atom nanozymes for electrochemical sensing oxidative stress biomarkers

Abstract

Keywords

ASJC Scopus subject areas

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