Slow evolutionary rate of GB virus C/hepatitis G virus

Yoshiyuki Suzuki; Kazuhiko Katayama; Shuetsu Fukushi; Tsutomu Kageyama; Akira Oya; Hirofumi Okamura; Yasuhito Tanaka; Masashi Mizokami; Takashi Gojobori

doi:10.1007/PL00006482

Slow evolutionary rate of GB virus C/hepatitis G virus

Yoshiyuki Suzuki, Kazuhiko Katayama, Shuetsu Fukushi, Tsutomu Kageyama, Akira Oya, Hirofumi Okamura, Yasuhito Tanaka, Masashi Mizokami, Takashi Gojobori^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

With the aim of elucidating evolutionary features of GB virus C/hepatitis G virus (GBV-C/HGV), molecular evolutionary analyses were conducted using the entire coding region of this virus. In particular, the rate of nucleotide substitution for this virus was estimated to be less than 9.0 x 10^-6 per site per year, which was much slower than those for other RNA viruses. The phylogenetic tree reconstructed for GBV-C/HGV, by using GB virus A (GBV-A) as outgroup, indicated that there were three major clusters (the HG, GB, and Asian types) in GBV-C/HGV, and the divergence between the ancestor of GB- and Asian-type strains and that of HG-type strains first took place more than 7000-10,000 years ago. The slow evolutionary rate for GBV- C/HGV suggested that this virus cannot escape from the immune response of the host by means of producing escape mutants, implying that it may have evolved other systems for persistent infection.

Original language	English (US)
Pages (from-to)	383-389
Number of pages	7
Journal	Journal of Molecular Evolution
Volume	48
Issue number	4
DOIs	https://doi.org/10.1007/PL00006482
State	Published - 1999
Externally published	Yes

Keywords

Divergence time
GBV-A
GBV-C/HGV
Phylogenetic tree
Substitution rate

ASJC Scopus subject areas

Ecology, Evolution, Behavior and Systematics
Molecular Biology
Genetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/PL00006482

Cite this

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title = "Slow evolutionary rate of GB virus C/hepatitis G virus",

abstract = "With the aim of elucidating evolutionary features of GB virus C/hepatitis G virus (GBV-C/HGV), molecular evolutionary analyses were conducted using the entire coding region of this virus. In particular, the rate of nucleotide substitution for this virus was estimated to be less than 9.0 x 10-6 per site per year, which was much slower than those for other RNA viruses. The phylogenetic tree reconstructed for GBV-C/HGV, by using GB virus A (GBV-A) as outgroup, indicated that there were three major clusters (the HG, GB, and Asian types) in GBV-C/HGV, and the divergence between the ancestor of GB- and Asian-type strains and that of HG-type strains first took place more than 7000-10,000 years ago. The slow evolutionary rate for GBV- C/HGV suggested that this virus cannot escape from the immune response of the host by means of producing escape mutants, implying that it may have evolved other systems for persistent infection.",

keywords = "Divergence time, GBV-A, GBV-C/HGV, Phylogenetic tree, Substitution rate",

author = "Yoshiyuki Suzuki and Kazuhiko Katayama and Shuetsu Fukushi and Tsutomu Kageyama and Akira Oya and Hirofumi Okamura and Yasuhito Tanaka and Masashi Mizokami and Takashi Gojobori",

year = "1999",

doi = "10.1007/PL00006482",

language = "English (US)",

volume = "48",

pages = "383--389",

journal = "Journal of Molecular Evolution",

issn = "0022-2844",

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T1 - Slow evolutionary rate of GB virus C/hepatitis G virus

AU - Suzuki, Yoshiyuki

AU - Katayama, Kazuhiko

AU - Fukushi, Shuetsu

AU - Kageyama, Tsutomu

AU - Oya, Akira

AU - Okamura, Hirofumi

AU - Tanaka, Yasuhito

AU - Mizokami, Masashi

AU - Gojobori, Takashi

PY - 1999

Y1 - 1999

N2 - With the aim of elucidating evolutionary features of GB virus C/hepatitis G virus (GBV-C/HGV), molecular evolutionary analyses were conducted using the entire coding region of this virus. In particular, the rate of nucleotide substitution for this virus was estimated to be less than 9.0 x 10-6 per site per year, which was much slower than those for other RNA viruses. The phylogenetic tree reconstructed for GBV-C/HGV, by using GB virus A (GBV-A) as outgroup, indicated that there were three major clusters (the HG, GB, and Asian types) in GBV-C/HGV, and the divergence between the ancestor of GB- and Asian-type strains and that of HG-type strains first took place more than 7000-10,000 years ago. The slow evolutionary rate for GBV- C/HGV suggested that this virus cannot escape from the immune response of the host by means of producing escape mutants, implying that it may have evolved other systems for persistent infection.

AB - With the aim of elucidating evolutionary features of GB virus C/hepatitis G virus (GBV-C/HGV), molecular evolutionary analyses were conducted using the entire coding region of this virus. In particular, the rate of nucleotide substitution for this virus was estimated to be less than 9.0 x 10-6 per site per year, which was much slower than those for other RNA viruses. The phylogenetic tree reconstructed for GBV-C/HGV, by using GB virus A (GBV-A) as outgroup, indicated that there were three major clusters (the HG, GB, and Asian types) in GBV-C/HGV, and the divergence between the ancestor of GB- and Asian-type strains and that of HG-type strains first took place more than 7000-10,000 years ago. The slow evolutionary rate for GBV- C/HGV suggested that this virus cannot escape from the immune response of the host by means of producing escape mutants, implying that it may have evolved other systems for persistent infection.

KW - Divergence time

KW - GBV-A

KW - GBV-C/HGV

KW - Phylogenetic tree

KW - Substitution rate

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U2 - 10.1007/PL00006482

DO - 10.1007/PL00006482

M3 - Article

C2 - 10079276

AN - SCOPUS:0033041307

SN - 0022-2844

VL - 48

SP - 383

EP - 389

JO - Journal of Molecular Evolution

JF - Journal of Molecular Evolution

IS - 4

ER -

Slow evolutionary rate of GB virus C/hepatitis G virus

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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