SMotif: A server for structural motifs in proteins

Ganesan Pugalenthi; P. N. Suganthan; R. Sowdhamini; Saikat Chakrabarti

doi:10.1093/bioinformatics/btl679

SMotif: A server for structural motifs in proteins

Ganesan Pugalenthi, P. N. Suganthan^*, R. Sowdhamini, Saikat Chakrabarti

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Summary: SMotif is a server that identifies important structural segments or motifs for a given protein structure(s) based on conservation of both sequential as well as important structural features such as solvent inaccessibility, secondary structural content, hydrogen bonding pattern and residue packing. This server also provides three-dimensional orientation patterns of the identified motifs in terms of inter-motif distances and torsion angles. These motifs may form the common core and therefore, can also be employed to design and rationalize protein engineering and folding experiments.

Original language	English (US)
Pages (from-to)	637-638
Number of pages	2
Journal	Bioinformatics
Volume	23
Issue number	5
DOIs	https://doi.org/10.1093/bioinformatics/btl679
State	Published - Mar 2007
Externally published	Yes

ASJC Scopus subject areas

Statistics and Probability
Biochemistry
Molecular Biology
Computer Science Applications
Computational Theory and Mathematics
Computational Mathematics

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title = "SMotif: A server for structural motifs in proteins",

abstract = "Summary: SMotif is a server that identifies important structural segments or motifs for a given protein structure(s) based on conservation of both sequential as well as important structural features such as solvent inaccessibility, secondary structural content, hydrogen bonding pattern and residue packing. This server also provides three-dimensional orientation patterns of the identified motifs in terms of inter-motif distances and torsion angles. These motifs may form the common core and therefore, can also be employed to design and rationalize protein engineering and folding experiments.",

author = "Ganesan Pugalenthi and Suganthan, {P. N.} and R. Sowdhamini and Saikat Chakrabarti",

note = "Funding Information: We thank Shameer Khadar for his help in installing the SMotif server. G.P. and P.N.S. acknowledge the financial support offered by the A*Star (Agency for Science, Technology and Research). S.C. acknowledges Intramural Research Program of the National Library of Medicine at NIH/DHHS. R.S. acknowledges National Centre for Biological Sciences (TIFR) for infrastructural support. Funding to pay the Open Access publication charges was provided by the Wellcome Trust, UK, as part of the Senior Research Fellowship of R.S.",

year = "2007",

month = mar,

doi = "10.1093/bioinformatics/btl679",

language = "English (US)",

volume = "23",

pages = "637--638",

journal = "Bioinformatics",

issn = "1367-4803",

publisher = "Oxford University Press",

number = "5",

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TY - JOUR

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T2 - A server for structural motifs in proteins

AU - Pugalenthi, Ganesan

AU - Suganthan, P. N.

AU - Sowdhamini, R.

AU - Chakrabarti, Saikat

N1 - Funding Information: We thank Shameer Khadar for his help in installing the SMotif server. G.P. and P.N.S. acknowledge the financial support offered by the A*Star (Agency for Science, Technology and Research). S.C. acknowledges Intramural Research Program of the National Library of Medicine at NIH/DHHS. R.S. acknowledges National Centre for Biological Sciences (TIFR) for infrastructural support. Funding to pay the Open Access publication charges was provided by the Wellcome Trust, UK, as part of the Senior Research Fellowship of R.S.

PY - 2007/3

Y1 - 2007/3

N2 - Summary: SMotif is a server that identifies important structural segments or motifs for a given protein structure(s) based on conservation of both sequential as well as important structural features such as solvent inaccessibility, secondary structural content, hydrogen bonding pattern and residue packing. This server also provides three-dimensional orientation patterns of the identified motifs in terms of inter-motif distances and torsion angles. These motifs may form the common core and therefore, can also be employed to design and rationalize protein engineering and folding experiments.

AB - Summary: SMotif is a server that identifies important structural segments or motifs for a given protein structure(s) based on conservation of both sequential as well as important structural features such as solvent inaccessibility, secondary structural content, hydrogen bonding pattern and residue packing. This server also provides three-dimensional orientation patterns of the identified motifs in terms of inter-motif distances and torsion angles. These motifs may form the common core and therefore, can also be employed to design and rationalize protein engineering and folding experiments.

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DO - 10.1093/bioinformatics/btl679

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JO - Bioinformatics

JF - Bioinformatics

IS - 5

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SMotif: A server for structural motifs in proteins

Abstract

ASJC Scopus subject areas

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