Solubility of Δ9-tetrahydrocannabinol in supercritical carbon dioxide: Experiments and modeling

Helene Perrotin-Brunel*, Pablo Cabeza Perez, Maaike J.E. van Roosmalen, Jaap van Spronsen, Geert Jan Witkamp, Cor J. Peters

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

58 Scopus citations


The solubility of Δ9-tetrahydrocannabinol (Δ9-THC) in supercritical carbon dioxide has been determined at 315, 327, 334 and 345 K and in the pressure range from 13.2 to 25.1 MPa using an analytical method with a quasi-flow apparatus. Prior to performing these measurements, the method was validated by measuring anthracene solubilities and comparing these with literature values. The molar solubility for Δ9-THC ranged from 0.20 to 2.95 × 10-4. The data were correlated using the Peng-Robinson equation of state in combination with quadratic mixing rules. Deviations between calculated results and the experimental data ranged from 4.1 to 13.3% absolute average relative deviation (AARD).

Original languageEnglish (US)
Pages (from-to)6-10
Number of pages5
JournalJournal of Supercritical Fluids
Issue number1
StatePublished - Feb 2010
Externally publishedYes


  • Anthracene
  • Peng-Robinson equation of state
  • Solubility
  • Supercritical carbon dioxide
  • Δ-Tetrahydrocannabinol

ASJC Scopus subject areas

  • General Chemical Engineering
  • Condensed Matter Physics
  • Physical and Theoretical Chemistry


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