Solubility of cannabinol in supercritical carbon dioxide

Helene Perrotin-Brunel; Maaike J.E. Van Roosmalen; Maaike C. Kroon; Jaap Van Spronsen; Geert Jan Witkamp; Cor J. Peters

doi:10.1021/je100245n

Solubility of cannabinol in supercritical carbon dioxide

Helene Perrotin-Brunel^*, Maaike J.E. Van Roosmalen, Maaike C. Kroon, Jaap Van Spronsen, Geert Jan Witkamp, Cor J. Peters

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Cannabinol (CBN) is a decomposition product of the cannabinoid (-)-Δ⁹-tetrahydrocannabinol (Δ⁹-THC), the main active compound of cannabis. The solubility of CBN in supercritical carbon dioxide was determined at (314, 327, and 334) K and in the pressure range from (13.0 to 20.2) MPa by using an analytical method with a quasi-flow apparatus. The molar solubility of CBN ranged from 1.26·10^-4 to 4.16·10^-4. CBN showed different behavior compared to Δ⁹-THC in terms of molar solubility. The data were correlated using the Peng-Robinson equation of state in combination with quadratic mixing rules. Deviations between calculated results and the experimental data ranged from (4.14 to 4.46) % absolute average relative deviation (AARD).

Original language	English (US)
Pages (from-to)	3704-3707
Number of pages	4
Journal	Journal of Chemical and Engineering Data
Volume	55
Issue number	9
DOIs	https://doi.org/10.1021/je100245n
State	Published - Sep 9 2010
Externally published	Yes

ASJC Scopus subject areas

General Chemistry
General Chemical Engineering

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title = "Solubility of cannabinol in supercritical carbon dioxide",

abstract = "Cannabinol (CBN) is a decomposition product of the cannabinoid (-)-Δ9-tetrahydrocannabinol (Δ9-THC), the main active compound of cannabis. The solubility of CBN in supercritical carbon dioxide was determined at (314, 327, and 334) K and in the pressure range from (13.0 to 20.2) MPa by using an analytical method with a quasi-flow apparatus. The molar solubility of CBN ranged from 1.26·10-4 to 4.16·10-4. CBN showed different behavior compared to Δ9-THC in terms of molar solubility. The data were correlated using the Peng-Robinson equation of state in combination with quadratic mixing rules. Deviations between calculated results and the experimental data ranged from (4.14 to 4.46) % absolute average relative deviation (AARD).",

author = "Helene Perrotin-Brunel and {Van Roosmalen}, {Maaike J.E.} and Kroon, {Maaike C.} and {Van Spronsen}, Jaap and Witkamp, {Geert Jan} and Peters, {Cor J.}",

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T1 - Solubility of cannabinol in supercritical carbon dioxide

AU - Perrotin-Brunel, Helene

AU - Van Roosmalen, Maaike J.E.

AU - Kroon, Maaike C.

AU - Van Spronsen, Jaap

AU - Witkamp, Geert Jan

AU - Peters, Cor J.

PY - 2010/9/9

Y1 - 2010/9/9

N2 - Cannabinol (CBN) is a decomposition product of the cannabinoid (-)-Δ9-tetrahydrocannabinol (Δ9-THC), the main active compound of cannabis. The solubility of CBN in supercritical carbon dioxide was determined at (314, 327, and 334) K and in the pressure range from (13.0 to 20.2) MPa by using an analytical method with a quasi-flow apparatus. The molar solubility of CBN ranged from 1.26·10-4 to 4.16·10-4. CBN showed different behavior compared to Δ9-THC in terms of molar solubility. The data were correlated using the Peng-Robinson equation of state in combination with quadratic mixing rules. Deviations between calculated results and the experimental data ranged from (4.14 to 4.46) % absolute average relative deviation (AARD).

AB - Cannabinol (CBN) is a decomposition product of the cannabinoid (-)-Δ9-tetrahydrocannabinol (Δ9-THC), the main active compound of cannabis. The solubility of CBN in supercritical carbon dioxide was determined at (314, 327, and 334) K and in the pressure range from (13.0 to 20.2) MPa by using an analytical method with a quasi-flow apparatus. The molar solubility of CBN ranged from 1.26·10-4 to 4.16·10-4. CBN showed different behavior compared to Δ9-THC in terms of molar solubility. The data were correlated using the Peng-Robinson equation of state in combination with quadratic mixing rules. Deviations between calculated results and the experimental data ranged from (4.14 to 4.46) % absolute average relative deviation (AARD).

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Solubility of cannabinol in supercritical carbon dioxide

Abstract

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