Solubility of non-psychoactive cannabinoids in supercritical carbon dioxide and comparison with psychoactive cannabinoids

Helene Perrotin-Brunel*, Maaike C. Kroon, Maaike J.E. Van Roosmalen, Jaap Van Spronsen, Cor J. Peters, Geert Jan Witkamp

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

59 Scopus citations


The solubilities of two different non-psychoactive cannabinoids i.e., cannabigerol (CBG) and cannabidiol (CBD), in supercritical carbon dioxide (CO2) have been determined at 315, 326 and 334 K and in the pressure range from 11.3 to 20.6 MPa. These solubility data have been compared to the previously determined solubilities of two psychoactive cannabinoids i.e., (-)-Δ9-tetrahydrocannabinol (Δ9-THC) and cannabinol (CBN), in supercritical CO2. An analytical method with a quasi-flow apparatus was used for the experimental determination. Within the investigated temperature and pressure range, the molar solubility of CBG ranged from 1.17 to 1.91 × 10-4 and the molar solubility of CBD ranged from 0.88 to 2.69 × 10-4. The solubility of the different cannabinoids in supercritical CO2 increases at 326 K in the following order: Δ9-THC < CBG < CBD < CBN. The solubility data were correlated using the Peng-Robinson equation of state in combination with Van der Waals mixing rules. Deviations between calculated results and the experimental data ranged from 0.81 to 6.35% absolute average relative deviation (AARD), except for CBD at 334 K, where the AARD was 18.4%.

Original languageEnglish (US)
Pages (from-to)603-608
Number of pages6
JournalJournal of Supercritical Fluids
Issue number2
StatePublished - Dec 2010
Externally publishedYes


  • Cannabidiol
  • Cannabigerol
  • Cannabinoids
  • Peng-Robinson equation of state
  • Solubility
  • Supercritical carbon dioxide
  • Van der Waals mixing rules

ASJC Scopus subject areas

  • General Chemical Engineering
  • Condensed Matter Physics
  • Physical and Theoretical Chemistry


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