Stem cells and interspecies chimaeras

Jun Wu; Henry T. Greely; Rudolf Jaenisch; Hiromitsu Nakauchi; Janet Rossant; Juan Carlos Izpisua Belmonte

doi:10.1038/nature20573

Stem cells and interspecies chimaeras

Jun Wu, Henry T. Greely, Rudolf Jaenisch, Hiromitsu Nakauchi, Janet Rossant, Juan Carlos Izpisua Belmonte^*

^*Corresponding author for this work

Biological, Environmental Sciences and Engineering

Research output: Contribution to journal › Review article › peer-review

134 Scopus citations

Abstract

Chimaeras are both monsters of the ancient imagination and a long-established research tool. Recent advances, particularly those dealing with the identification and generation of various kinds of stem cells, have broadened the repertoire and utility of mammalian interspecies chimaeras and carved out new paths towards understanding fundamental biology as well as potential clinical applications.

Original language	English (US)
Pages (from-to)	51-59
Number of pages	9
Journal	NATURE
Volume	540
Issue number	7631
DOIs	https://doi.org/10.1038/nature20573
State	Published - Dec 1 2016

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title = "Stem cells and interspecies chimaeras",

abstract = "Chimaeras are both monsters of the ancient imagination and a long-established research tool. Recent advances, particularly those dealing with the identification and generation of various kinds of stem cells, have broadened the repertoire and utility of mammalian interspecies chimaeras and carved out new paths towards understanding fundamental biology as well as potential clinical applications.",

author = "Jun Wu and Greely, {Henry T.} and Rudolf Jaenisch and Hiromitsu Nakauchi and Janet Rossant and Belmonte, {Juan Carlos Izpisua}",

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AU - Wu, Jun

AU - Greely, Henry T.

AU - Jaenisch, Rudolf

AU - Nakauchi, Hiromitsu

AU - Rossant, Janet

AU - Belmonte, Juan Carlos Izpisua

PY - 2016/12/1

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AB - Chimaeras are both monsters of the ancient imagination and a long-established research tool. Recent advances, particularly those dealing with the identification and generation of various kinds of stem cells, have broadened the repertoire and utility of mammalian interspecies chimaeras and carved out new paths towards understanding fundamental biology as well as potential clinical applications.

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U2 - 10.1038/nature20573

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JO - NATURE

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Stem cells and interspecies chimaeras

Abstract

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