@article{aa85c7cef7fa4466a694177c8e4031f4,
title = "Stereotyped patterns of B-cell receptor in splenic marginal zone lymphoma",
abstract = "Antigen stimulation may be important for splenic marginal zone lymphoma pathogenesis. To address this hypothesis, the occurrence of stereotyped B-cell receptors was investigated in 133 SMZL (26 HCV+) compared with 4,414 HCDR3 sequences from public databases. Sixteen SMZL (12%) showed stereotyped BCR; 7 of 86 (8%) SMZL sequences retrieved from public databases also belonged to stereotyped HCDR3 subsets. Three categories of subsets were identified: i) SMZL-specific subsets (n=5), composed only of 12 SMZL (9 HCV- from our series); ii) Non-Hodgkin's lymphoma-like subsets (n=5), comprising 5 SMZL (4 from our series) clustering with other indolent lymphomas; iii) {"}CLL-like subsets{"} (n=6), comprising 6 SMZL (3 from our series) that belonged to known CLL subsets (n=4) or clustered with public CLL sequences. Immunoglobulin 3D modeling of 3 subsets revealed similarities in antigen binding regions not limited to HCDR3. Overall, data suggest that the pathogenesis of splenic marginal zone lymphoma may involve also HCV unrelated epitopes or an antigenic trigger common to other indolent lymphomas. {\textcopyright}2010 Ferrata Storti Foundation.",
author = "S. Zibellini and D. Capello and F. Forconi and P. Marcatili and D. Rossi and S. Rattotti and S. Franceschetti and E. Sozzi and E. Cencini and R. Marasca and L. Baldini and A. Tucci and F. Bertoni and F. Passamonti and E. Orlandi and M. Varettoni and M. Merli and S. Rizzi and V. Gattei and A. Tramontano and M. Paulli and G. Gaidano and L. Arcaini",
note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledged KAUST grant number(s): KUK-I1-012-43 Acknowledgements: the authors wish to thank Prof. Andrea Mattevi for helpful discussion. The authors are also grateful to Cristiana Pascutto and Virginia Ferretti for statistical analysis. This publication is based on work partially supported by Ricerca Sanitaria Finalizzata 2008 and 2009, Regione Piemonte, Torino, Italy (to DC, DR and GG); Progetto Integrato Oncologia and Programma di Ricerca di Rilevante Interesse Nazionale (PRIN) 2008, Ministero della Salute, Rome, Italy (to GG); Progetto Giovani Ricercatori 2008 Ministero della Salute, Rome, Italy (to DR); Novara-Associazione Italiana contro le Leucemie, Linfomi e Mielomi (AIL) Onlus, Novara, Italy (to GG, DR); AIL, Venezia Section, Pramaggiore Group, Pramaggiore (VE), Italy (to VG); Associazione Italiana per la Ricerca contro il Cancro, Milan, Italy (to FF, ES, EC and VG); Ministero della Salute (Ricerca Finalizzata IRCCS., “Alleanza Contro il Cancro” and Rete Nazionale Bio-Informatica Oncologica/RN-BIO), Rome, Italy (to VG); Ricerca Scientifica Applicata, Regione Friuli-Venezia-Giulia, Trieste (“Linfonet” Project), Italy (to VG); Award No. KUK-I1-012-43, made by King Abdullah University of Science and Technology (KAUST) (to AT and PM); Oncosuisse grant OCS-02034-02-2007 (to FB); Fondazione per la Ricerca e la Cura sui Linfomi, Lugano, Switzerland (to FB). This publication acknowledges KAUST support, but has no KAUST affiliated authors.",
year = "2010",
month = may,
day = "29",
doi = "10.3324/haematol.2010.025437",
language = "English (US)",
volume = "95",
pages = "1792--1796",
journal = "Haematologica",
issn = "0390-6078",
publisher = "Ferrata Storti Foundation",
number = "10",
}