TY - JOUR
T1 - Stimuli-Responsive Lysozyme Nanocapsule Engineered Microfiltration Membranes with a Dual-Function of Anti-Adhesion and Antibacteria for Biofouling Mitigation
AU - Li, Sihang
AU - Zhao, Shuzhen
AU - Pei, Jianfei
AU - Wang, Haihua
AU - Meng, Huanna
AU - Vrouwenvelder, Johannes S.
AU - Li, Zhenyu
N1 - KAUST Repository Item: Exported on 2021-07-08
Acknowledgements: The authors gratefully acknowledge the funding support by The National Key R&D Plan for International Cooperation in Science and Technology Innovation (project no. 2017YFE0181100) and the National Nature Science Foundation of China (project no. 21901212).
PY - 2021/7/5
Y1 - 2021/7/5
N2 - Biofouling remains as a persistent problem impeding the applications of membranes for water and wastewater treatment. Green anti-biofouling of membranes made of natural and environmentally friendly materials and methods is a promising strategy to tackle this problem. Herein, we have developed a functionalized PVDF membrane with stimuli-responsive lysozyme nanocapsules (NCP). These nanocapsules can responsively release lysozyme according to environmental stimuli (pH and redox) induced by bacteria. Results showed that (i) the surface of the functionalized membrane with NCP had enhanced hydrophilicity, reduced roughness, and negative charge, (ii) a remarkable reduction of adsorption of proteins, polysaccharides, and bacteria was achieved by the functionalized membrane, and (iii) the colony forming unit (CFU) of bacteria on a membrane surface was reduced more than 80% within 24 h of contact. In addition, the NCP membrane showed excellent anti-biofouling activity regarding the bacterial viability being 12.5 and 8.3% on the membrane after filtration with 108 CFU mL–1Escherichia coli and Staphylococcus aureus solution as feed, respectively. The coating layer and assembled nanocapsules endowed the membrane with improved lysozyme stability, anti-adhesion performance, and antibacterial activity. Stimuli-responsive lysozyme nanocapsule engineered microfiltration membranes show great potential for anti-biofouling in future practical application.
AB - Biofouling remains as a persistent problem impeding the applications of membranes for water and wastewater treatment. Green anti-biofouling of membranes made of natural and environmentally friendly materials and methods is a promising strategy to tackle this problem. Herein, we have developed a functionalized PVDF membrane with stimuli-responsive lysozyme nanocapsules (NCP). These nanocapsules can responsively release lysozyme according to environmental stimuli (pH and redox) induced by bacteria. Results showed that (i) the surface of the functionalized membrane with NCP had enhanced hydrophilicity, reduced roughness, and negative charge, (ii) a remarkable reduction of adsorption of proteins, polysaccharides, and bacteria was achieved by the functionalized membrane, and (iii) the colony forming unit (CFU) of bacteria on a membrane surface was reduced more than 80% within 24 h of contact. In addition, the NCP membrane showed excellent anti-biofouling activity regarding the bacterial viability being 12.5 and 8.3% on the membrane after filtration with 108 CFU mL–1Escherichia coli and Staphylococcus aureus solution as feed, respectively. The coating layer and assembled nanocapsules endowed the membrane with improved lysozyme stability, anti-adhesion performance, and antibacterial activity. Stimuli-responsive lysozyme nanocapsule engineered microfiltration membranes show great potential for anti-biofouling in future practical application.
UR - http://hdl.handle.net/10754/670037
UR - https://pubs.acs.org/doi/10.1021/acsami.1c07445
U2 - 10.1021/acsami.1c07445
DO - 10.1021/acsami.1c07445
M3 - Article
C2 - 34225456
SN - 1944-8244
JO - ACS Applied Materials & Interfaces
JF - ACS Applied Materials & Interfaces
ER -