Structure and Reaction Mechanism of Pyrrolysine Synthase (PylD)

Felix Quitterer, Philipp Beck, Adelbert Bacher, Michael Groll

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


The final step in the biosynthesis of the 22nd genetically encoded amino acid, pyrrolysine, is catalyzed by PylD, a structurally and mechanistically unique dehydrogenase. This catalyzed reaction includes an induced-fit mechanism achieved by major structural rearrangements of the N-terminal helix upon substrate binding. Different steps of the reaction trajectory are visualized by complex structures of PylD with substrate and product. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Original languageEnglish (US)
Pages (from-to)7033-7037
Number of pages5
JournalAngewandte Chemie International Edition
Issue number27
StatePublished - May 29 2013
Externally publishedYes


Dive into the research topics of 'Structure and Reaction Mechanism of Pyrrolysine Synthase (PylD)'. Together they form a unique fingerprint.

Cite this