Structure of polypeptide-based diblock copolymers in solution: Stimuli-responsive vesicles and micelles

Frédéric Chécot; Annie Brûlet; Julian Oberdisse; Yves Gnanou; Olivier Mondain-Monval; Sébastien Lecommandoux

doi:10.1021/la0468500

Structure of polypeptide-based diblock copolymers in solution: Stimuli-responsive vesicles and micelles

Frédéric Chécot, Annie Brûlet, Julian Oberdisse, Yves Gnanou, Olivier Mondain-Monval, Sébastien Lecommandoux^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

174 Scopus citations

Abstract

Polypeptide-based diblock copolymers forming either well-defined self-assembled micelles or vesicles after direct dissolution in water or in dichloromethane have been studied combining light and neutron scattering with electron microscopy experiments. The size of these structures could be reversibly manipulated as a function of environmental changes such as pH and ionic strength in water. Compared to other pH-responsive self-assembled systems based on "classical" poly electrolytes, these polypeptide-based nanostructures present the ability to give a response in highly salted media as the chain conformational ordering can be controlled. This makes these micelles and vesicles suitable for biological applications: they provide significant advantages in the control of the structure and function of supramolecular self-assemblies.

Original language	English (US)
Pages (from-to)	4308-4315
Number of pages	8
Journal	LANGMUIR
Volume	21
Issue number	10
DOIs	https://doi.org/10.1021/la0468500
State	Published - May 10 2005
Externally published	Yes

ASJC Scopus subject areas

General Materials Science
Condensed Matter Physics
Surfaces and Interfaces
Spectroscopy
Electrochemistry

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10.1021/la0468500

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AU - Chécot, Frédéric

AU - Brûlet, Annie

AU - Oberdisse, Julian

AU - Gnanou, Yves

AU - Mondain-Monval, Olivier

AU - Lecommandoux, Sébastien

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AB - Polypeptide-based diblock copolymers forming either well-defined self-assembled micelles or vesicles after direct dissolution in water or in dichloromethane have been studied combining light and neutron scattering with electron microscopy experiments. The size of these structures could be reversibly manipulated as a function of environmental changes such as pH and ionic strength in water. Compared to other pH-responsive self-assembled systems based on "classical" poly electrolytes, these polypeptide-based nanostructures present the ability to give a response in highly salted media as the chain conformational ordering can be controlled. This makes these micelles and vesicles suitable for biological applications: they provide significant advantages in the control of the structure and function of supramolecular self-assemblies.

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Structure of polypeptide-based diblock copolymers in solution: Stimuli-responsive vesicles and micelles

Abstract

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