Structure of polypeptide-based diblock copolymers in solution: Stimuli-responsive vesicles and micelles

Frédéric Chécot, Annie Brûlet, Julian Oberdisse, Yves Gnanou, Olivier Mondain-Monval, Sébastien Lecommandoux*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

170 Scopus citations


Polypeptide-based diblock copolymers forming either well-defined self-assembled micelles or vesicles after direct dissolution in water or in dichloromethane have been studied combining light and neutron scattering with electron microscopy experiments. The size of these structures could be reversibly manipulated as a function of environmental changes such as pH and ionic strength in water. Compared to other pH-responsive self-assembled systems based on "classical" poly electrolytes, these polypeptide-based nanostructures present the ability to give a response in highly salted media as the chain conformational ordering can be controlled. This makes these micelles and vesicles suitable for biological applications: they provide significant advantages in the control of the structure and function of supramolecular self-assemblies.

Original languageEnglish (US)
Pages (from-to)4308-4315
Number of pages8
Issue number10
StatePublished - May 10 2005
Externally publishedYes

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry


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