Surface engineered nanoparticles for oral immunization

Basant Malik, Amit K. Goyal, Foziyah Zakir, S. P. Vyas

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

A rationally designed oral vaccine should be successfully delivered to the intestinal mucosal immune cells, and induce both humoral and cellular counterparts of immunity along with the mucosal immune response. The aim of this study is to mimic these natural infections and excel the utility of a specific ligand for β1 integrin (RGD peptide) to target M cells which seems to be the only portal for any particulate matter in GIT. The in vivo studies have shown higher antibody titre for alginate coated chitosan nanoparticles compared to plain chitosan nanoparticles. RGD peptide conjugated alginate coated chitosan nanoparticles proved to be the suitable carrier system for antigen delivery to gut associated lymphoid tissue. Based upon the release kinetics and strong systemic as well as mucosal immune response we can conclude that this cost effective carrier construct can be utilized for oral vaccination. Copyright © 2011 American Scientific Publishers All rights reserved.
Original languageEnglish (US)
Pages (from-to)132-134
Number of pages3
JournalJournal of Biomedical Nanotechnology
Volume7
Issue number1
DOIs
StatePublished - Jan 1 2011
Externally publishedYes

ASJC Scopus subject areas

  • Biomedical Engineering
  • Bioengineering
  • Pharmaceutical Science
  • Materials Science(all)
  • Medicine (miscellaneous)

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