Synthesis of Amidines from Amides Using a Nickel-Catalyzed Decarbonylative Amination through CO Extrusion Intramolecular Recombination Fragment Coupling

Xiangqian Liu; Huifeng Yue; Jiaqi Jia; Lin Guo; Magnus Rueping

doi:10.1002/chem.201702867

Synthesis of Amidines from Amides Using a Nickel-Catalyzed Decarbonylative Amination through CO Extrusion Intramolecular Recombination Fragment Coupling

Xiangqian Liu, Huifeng Yue, Jiaqi Jia, Lin Guo, Magnus Rueping^*

^*Corresponding author for this work

Physical Sciences and Engineering

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

A catalytic synthesis of amidines from amides has been established for the first time. The newly developed CO extrusion recombination process takes advantage of an inexpensive nickel(II) catalyst and provides the corresponding amidines with high efficiency. The intramolecular fragment coupling shows excellent chemoselectivity, starts from readily available amides, and provides a valuable alternative amidine synthesis protocol.

Original language	English (US)
Pages (from-to)	11771-11775
Number of pages	5
Journal	Chemistry - A European Journal
Volume	23
Issue number	49
DOIs	https://doi.org/10.1002/chem.201702867
State	Published - Sep 4 2017

Keywords

C−N activation
amide
amine
nickel catalysis
synthetic methods

ASJC Scopus subject areas

Catalysis
General Chemistry
Organic Chemistry

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10.1002/chem.201702867

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title = "Synthesis of Amidines from Amides Using a Nickel-Catalyzed Decarbonylative Amination through CO Extrusion Intramolecular Recombination Fragment Coupling",

abstract = "A catalytic synthesis of amidines from amides has been established for the first time. The newly developed CO extrusion recombination process takes advantage of an inexpensive nickel(II) catalyst and provides the corresponding amidines with high efficiency. The intramolecular fragment coupling shows excellent chemoselectivity, starts from readily available amides, and provides a valuable alternative amidine synthesis protocol.",

keywords = "C−N activation, amide, amine, nickel catalysis, synthetic methods",

author = "Xiangqian Liu and Huifeng Yue and Jiaqi Jia and Lin Guo and Magnus Rueping",

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T1 - Synthesis of Amidines from Amides Using a Nickel-Catalyzed Decarbonylative Amination through CO Extrusion Intramolecular Recombination Fragment Coupling

AU - Liu, Xiangqian

AU - Yue, Huifeng

AU - Jia, Jiaqi

AU - Guo, Lin

AU - Rueping, Magnus

PY - 2017/9/4

Y1 - 2017/9/4

N2 - A catalytic synthesis of amidines from amides has been established for the first time. The newly developed CO extrusion recombination process takes advantage of an inexpensive nickel(II) catalyst and provides the corresponding amidines with high efficiency. The intramolecular fragment coupling shows excellent chemoselectivity, starts from readily available amides, and provides a valuable alternative amidine synthesis protocol.

AB - A catalytic synthesis of amidines from amides has been established for the first time. The newly developed CO extrusion recombination process takes advantage of an inexpensive nickel(II) catalyst and provides the corresponding amidines with high efficiency. The intramolecular fragment coupling shows excellent chemoselectivity, starts from readily available amides, and provides a valuable alternative amidine synthesis protocol.

KW - C−N activation

KW - amide

KW - amine

KW - nickel catalysis

KW - synthetic methods

UR - http://www.scopus.com/inward/record.url?scp=85028618127&partnerID=8YFLogxK

U2 - 10.1002/chem.201702867

DO - 10.1002/chem.201702867

M3 - Article

C2 - 28695654

AN - SCOPUS:85028618127

SN - 0947-6539

VL - 23

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JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

IS - 49

ER -

Synthesis of Amidines from Amides Using a Nickel-Catalyzed Decarbonylative Amination through CO Extrusion Intramolecular Recombination Fragment Coupling

Abstract

Keywords

ASJC Scopus subject areas

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