TY - JOUR
T1 - Synthesis of an amphiphilic dendrimer-like block copolymer and its application on drug delivery
AU - Wang, Shuaipeng
AU - Song, Xiaowan
AU - Feng, Xiaoshuang
AU - Chen, Peng
AU - Qian, Jiasheng
AU - Xia, Ru
AU - Miao, Jibin
N1 - KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: This work was supported by the National Natural Science Foundation of China (No.20804001, No.20974001, No.21174001, and No.51273001), the 211 Project, and the Incubation Fund for Excellent Young Researcher of Anhui University.
PY - 2014/10/27
Y1 - 2014/10/27
N2 - Dendrimer-like amphiphilic copolymer is a kind of three-dimensional spherical structure polymer. An amphiphilic dendrimer-like diblock copolymer, PEEGE-G2-b-PEO(OH)12, constituted of a hydrophobic poly(ethoxyethyl glycidol ether) inner core and a hydrophilic poly(ethylene oxide) outer layer, has been successfully synthesized by the living anionic ring-opening polymerization method. The intermediates and targeted products were characterized with 1H NMR spectroscopy and gel permeation chromatography. The application on drug delivery of dendrimer-like diblock copolymer PEEGE-G2-b-PEO(OH)12 using DOX as a model drug was also studied. The drug loading content and encapsulation efficiency were found at 13.07% and 45.75%, respectively. In vitro release experiment results indicated that the drug-loaded micelles exhibited a sustained release behavior under acidic media.
AB - Dendrimer-like amphiphilic copolymer is a kind of three-dimensional spherical structure polymer. An amphiphilic dendrimer-like diblock copolymer, PEEGE-G2-b-PEO(OH)12, constituted of a hydrophobic poly(ethoxyethyl glycidol ether) inner core and a hydrophilic poly(ethylene oxide) outer layer, has been successfully synthesized by the living anionic ring-opening polymerization method. The intermediates and targeted products were characterized with 1H NMR spectroscopy and gel permeation chromatography. The application on drug delivery of dendrimer-like diblock copolymer PEEGE-G2-b-PEO(OH)12 using DOX as a model drug was also studied. The drug loading content and encapsulation efficiency were found at 13.07% and 45.75%, respectively. In vitro release experiment results indicated that the drug-loaded micelles exhibited a sustained release behavior under acidic media.
UR - http://hdl.handle.net/10754/563806
UR - http://cps.scitation.org/doi/10.1063/1674-0068/27/05/587-592
UR - http://www.scopus.com/inward/record.url?scp=84908673498&partnerID=8YFLogxK
U2 - 10.1063/1674-0068/27/05/587-592
DO - 10.1063/1674-0068/27/05/587-592
M3 - Article
SN - 1674-0068
VL - 27
SP - 587
EP - 592
JO - Chinese Journal of Chemical Physics
JF - Chinese Journal of Chemical Physics
IS - 5
ER -