Synthesis of dendritic polyamides via a convergent growth approach

Kathryn E. Uhrich, Jean M.J. Fréchet*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


The synthesis of dendritic polyamides by the convergent growth approach is described. The synthesis involves an A2B monomer, N-(tert-butoxycarbonyl)iminodipropionic acid, containing two free carboxylic acid groups and a protected amine. The polycondensation reaction is carried out using classical peptide chemistry with sequential coupling-deprotection steps to afford polyamides with molecular weights up to 5000. As their size increases, the dendritic polyamide find their growth restricted by steric problems. The final step of growth is the condensation of the dendrimers with a trifunctional acid chloride core to give the final globular polyamides. The macromolecules were characterised by a variety of chromatographic and spectroscopic techniques, and were found to have precisely defined structures.

Original languageEnglish (US)
Pages (from-to)1623-1630
Number of pages8
JournalJournal of the Chemical Society, Perkin Transactions 1
Issue number13
StatePublished - 1992
Externally publishedYes

ASJC Scopus subject areas

  • General Chemistry


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