TY - JOUR
T1 - Synthesis of well-defined functional macromolecular chimeras based on poly(ethylene oxide) or poly(N-vinyl pyrrolidone)
AU - Karatzas, A.
AU - Bilalis, P.
AU - Iatrou, H.
AU - Pitsikalis, M.
AU - Hadjichristidis, N.
N1 - Funding Information:
The financial support of the Ministry of Education through the Operational Program and Initial Educational Vocational Training on “Polymer Science and its Applications” and the Research Committee of the University of Athens is greatly appreciated.
PY - 2009/7
Y1 - 2009/7
N2 - By using either NH2-functionalized linear/4-arm star poly(ethylene oxide) or NH2-TEMPO initiator, the following novel polymer/polypeptide hybrids (macromolecular chimeras) of poly(ethylene oxide), PEO and poly(N-vinyl pyrrolidone), PNVP, were synthesized: PEO-b-(PBLG or PBLL), PEO-b-PBLL-b-PBLG, 4-arm star copolymer (PEO-b-PBLG)4, PNVP-b-PBLG-b-PBLL, where PBLG is poly(γ-benzyl-l-glutamate) and PBLL, poly(tert-butyloxycarbonyl-l-lysine). The amino-groups are used for the ring opening polymerization (ROP) of α-amino acid carboxyanhydrides (NCAs), while TEMPO was employed for the polymerization of NVP. Molecular characterization revealed the high molecular weight and compositional homogeneity of the macromolecular chimeras prepared. The success of the synthesis was based on the recently developed living ROP of NCAs and controlled/living TEMPO polymerization, using high vacuum techniques.
AB - By using either NH2-functionalized linear/4-arm star poly(ethylene oxide) or NH2-TEMPO initiator, the following novel polymer/polypeptide hybrids (macromolecular chimeras) of poly(ethylene oxide), PEO and poly(N-vinyl pyrrolidone), PNVP, were synthesized: PEO-b-(PBLG or PBLL), PEO-b-PBLL-b-PBLG, 4-arm star copolymer (PEO-b-PBLG)4, PNVP-b-PBLG-b-PBLL, where PBLG is poly(γ-benzyl-l-glutamate) and PBLL, poly(tert-butyloxycarbonyl-l-lysine). The amino-groups are used for the ring opening polymerization (ROP) of α-amino acid carboxyanhydrides (NCAs), while TEMPO was employed for the polymerization of NVP. Molecular characterization revealed the high molecular weight and compositional homogeneity of the macromolecular chimeras prepared. The success of the synthesis was based on the recently developed living ROP of NCAs and controlled/living TEMPO polymerization, using high vacuum techniques.
KW - Nitroxide mediated radical polymerization
KW - Poly(N-vinyl pyrrolidone)
KW - Poly(ethylene oxide)
KW - Polypeptides
KW - Ring opening polymerization
UR - http://www.scopus.com/inward/record.url?scp=67349092890&partnerID=8YFLogxK
U2 - 10.1016/j.reactfunctpolym.2008.12.003
DO - 10.1016/j.reactfunctpolym.2008.12.003
M3 - Article
AN - SCOPUS:67349092890
SN - 1381-5148
VL - 69
SP - 435
EP - 440
JO - Reactive and Functional Polymers
JF - Reactive and Functional Polymers
IS - 7
ER -