Synthetic Vehicles for Encapsulation and Delivery of CRISPR/Cas9 Gene Editing Machinery

Valentina Carboni; Carine Maaliki; Mram Z. Alyami; Shahad K. Alsaiari; Niveen M. Khashab

doi:10.1002/adtp.201800085

Synthetic Vehicles for Encapsulation and Delivery of CRISPR/Cas9 Gene Editing Machinery

Valentina Carboni, Carine Maaliki, Mram Z. Alyami, Shahad K. Alsaiari, Niveen M. Khashab

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Abstract

Clustered regularly interspaced short palindromic repeat (CRISPR) and CRISPR-associated 9 (Cas-9) technology holds tremendous potential as a gene editing tool. Different strategies have been adopted for in vitro and in vivo delivery of CRISPR/Cas9, including both viral and non-viral. The possibility of tailoring properties of nanosized systems makes the molecular design of self-assembled non-viral delivery systems based on organic (lipids and polymers) and hybrid (zeolitic imidazolate frameworks, ZIF and gold nanoparticles) materials of a great interest in CRISPR/Cas9 delivery. This review highlights the progress and challenges of organic and hybrid CRISPR/Cas9 delivery vehicles.

Original language	English (US)
Pages (from-to)	1800085
Journal	Advanced Therapeutics
Volume	2
Issue number	4
DOIs	https://doi.org/10.1002/adtp.201800085
State	Published - Feb 10 2019

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10.1002/adtp.201800085

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abstract = "Clustered regularly interspaced short palindromic repeat (CRISPR) and CRISPR-associated 9 (Cas-9) technology holds tremendous potential as a gene editing tool. Different strategies have been adopted for in vitro and in vivo delivery of CRISPR/Cas9, including both viral and non-viral. The possibility of tailoring properties of nanosized systems makes the molecular design of self-assembled non-viral delivery systems based on organic (lipids and polymers) and hybrid (zeolitic imidazolate frameworks, ZIF and gold nanoparticles) materials of a great interest in CRISPR/Cas9 delivery. This review highlights the progress and challenges of organic and hybrid CRISPR/Cas9 delivery vehicles.",

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AU - Carboni, Valentina

AU - Maaliki, Carine

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AU - Alsaiari, Shahad K.

AU - Khashab, Niveen M.

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PY - 2019/2/10

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AB - Clustered regularly interspaced short palindromic repeat (CRISPR) and CRISPR-associated 9 (Cas-9) technology holds tremendous potential as a gene editing tool. Different strategies have been adopted for in vitro and in vivo delivery of CRISPR/Cas9, including both viral and non-viral. The possibility of tailoring properties of nanosized systems makes the molecular design of self-assembled non-viral delivery systems based on organic (lipids and polymers) and hybrid (zeolitic imidazolate frameworks, ZIF and gold nanoparticles) materials of a great interest in CRISPR/Cas9 delivery. This review highlights the progress and challenges of organic and hybrid CRISPR/Cas9 delivery vehicles.

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Synthetic Vehicles for Encapsulation and Delivery of CRISPR/Cas9 Gene Editing Machinery

Abstract

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