Talk is cheap - Cross-talk in establishment, maintenance, and readout of chromatin modifications

Wolfgang Fischle

doi:10.1101/gad.1759708

Talk is cheap - Cross-talk in establishment, maintenance, and readout of chromatin modifications

Wolfgang Fischle^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

41 Scopus citations

Abstract

The functionality of a cell's genome is controlled epigenetically on the level of chromatin. Multiple post-translational modifications of histone proteins together with DNA methylation play a key role in directing distinct functional states of chromatin. As it emerges, many epigenetic marks on the chromatin platform do not act independently, but cross-talk with each other. In this issue of Genes & Development, Adhvaryu and Selker (pp. 3391-3396) provide novel insights into an intricate regulatory network involving histone phosphorylation, histone methylation, and DNA methylation.

Original language	English (US)
Pages (from-to)	3375-3382
Number of pages	8
Journal	Genes and Development
Volume	22
Issue number	24
DOIs	https://doi.org/10.1101/gad.1759708
State	Published - Dec 15 2008
Externally published	Yes

Keywords

DNA methylation
Histone H3 Ser 10 phosphorylation
Histone H3 mutation
Neurospora crassa
Protein phosphatase PP1

ASJC Scopus subject areas

Genetics
Developmental Biology

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10.1101/gad.1759708

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AB - The functionality of a cell's genome is controlled epigenetically on the level of chromatin. Multiple post-translational modifications of histone proteins together with DNA methylation play a key role in directing distinct functional states of chromatin. As it emerges, many epigenetic marks on the chromatin platform do not act independently, but cross-talk with each other. In this issue of Genes & Development, Adhvaryu and Selker (pp. 3391-3396) provide novel insights into an intricate regulatory network involving histone phosphorylation, histone methylation, and DNA methylation.

KW - DNA methylation

KW - Histone H3 Ser 10 phosphorylation

KW - Histone H3 mutation

KW - Neurospora crassa

KW - Protein phosphatase PP1

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ER -

Talk is cheap - Cross-talk in establishment, maintenance, and readout of chromatin modifications

Abstract

Keywords

ASJC Scopus subject areas

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