TY - JOUR
T1 - TcoF-DB v2: update of the database of human and mouse transcription co-factors and transcription factor interactions
AU - Schmeier, Sebastian
AU - Alam, Tanvir
AU - Essack, Magbubah
AU - Bajic, Vladimir B.
N1 - KAUST Repository Item: Exported on 2020-10-01
Acknowledged KAUST grant number(s): URF/1/1976-02
Acknowledgements: King Abdullah University of Science and Technology (KAUST) base research fund (to T.A. and V.B.B.); KAUST Office of Sponsored Research (OSR) [URF/1/1976-02 to M.E.]. Funding for open access charge: KAUST.
PY - 2016/10/26
Y1 - 2016/10/26
N2 - Transcription factors (TFs) play a pivotal role in transcriptional regulation, making them crucial for cell survival and important biological functions. For the regulation of transcription, interactions of different regulatory proteins known as transcription co-factors (TcoFs) and TFs are essential in forming necessary protein complexes. Although TcoFs themselves do not bind DNA directly, their influence on transcriptional regulation and initiation, although indirect, has been shown to be significant, with the functionality of TFs strongly influenced by the presence of TcoFs. In the TcoF-DB v2 database, we collect information on TcoFs. In this article, we describe updates and improvements implemented in TcoF-DB v2. TcoF-DB v2 provides several new features that enables exploration of the roles of TcoFs. The content of the database has significantly expanded, and is enriched with information from Gene Ontology, biological pathways, diseases and molecular signatures. TcoF-DB v2 now includes many more TFs; has substantially increased the number of human TcoFs to 958, and now includes information on mouse (418 new TcoFs). TcoF-DB v2 enables the exploration of information on TcoFs and allows investigations into their influence on transcriptional regulation in humans and mice. TcoF-DB v2 can be accessed at http://tcofdb.org/.
AB - Transcription factors (TFs) play a pivotal role in transcriptional regulation, making them crucial for cell survival and important biological functions. For the regulation of transcription, interactions of different regulatory proteins known as transcription co-factors (TcoFs) and TFs are essential in forming necessary protein complexes. Although TcoFs themselves do not bind DNA directly, their influence on transcriptional regulation and initiation, although indirect, has been shown to be significant, with the functionality of TFs strongly influenced by the presence of TcoFs. In the TcoF-DB v2 database, we collect information on TcoFs. In this article, we describe updates and improvements implemented in TcoF-DB v2. TcoF-DB v2 provides several new features that enables exploration of the roles of TcoFs. The content of the database has significantly expanded, and is enriched with information from Gene Ontology, biological pathways, diseases and molecular signatures. TcoF-DB v2 now includes many more TFs; has substantially increased the number of human TcoFs to 958, and now includes information on mouse (418 new TcoFs). TcoF-DB v2 enables the exploration of information on TcoFs and allows investigations into their influence on transcriptional regulation in humans and mice. TcoF-DB v2 can be accessed at http://tcofdb.org/.
UR - http://hdl.handle.net/10754/622045
UR - https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/gkw1007
UR - http://www.scopus.com/inward/record.url?scp=85016025338&partnerID=8YFLogxK
U2 - 10.1093/nar/gkw1007
DO - 10.1093/nar/gkw1007
M3 - Article
C2 - 27789689
SN - 0305-1048
VL - 45
SP - D145-D150
JO - Nucleic Acids Research
JF - Nucleic Acids Research
IS - D1
ER -