Temperature-sensitive nanocapsule for drug delivery

M. V. Suyetin*, A. V. Vakhrushev

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


One of the most important applications of nanotechnology is to discover systems for targeted delivery of drugs, that is, designing nanocapsules (nanocontainers). Such nanocapsules have to take effect only in strictly localised areas to avoid drug action on healthy cells. The processes of doxorubicin storage and ejection by the carbon nanocapsule for drug delivery are studied by the method of molecular dynamics. The nanocapsule discussed consists of different nanotubes: (40,40), (10,10), (20,20) and (15,15) joint with each other by pentagonal and heptagonal rings. Nanocapsule stores doxorubicin molecule at normal human body temperature - 309.75K (36.6°C). The doxorubicin molecule is ejected owing to heating and further expansion of the gas inside the nanocapsule. The gas pushes the fullerene-piston, which ejects the doxorubicin molecule out of the nanocapsule. The temperature required for doxorubicin ejection is 316.75K (43.6°C). The temperature elevation can be reached with infrared radiation.

Original languageEnglish (US)
Pages (from-to)39-42
Number of pages4
JournalMicro and Nano Letters
Issue number1
StatePublished - Jan 2011
Externally publishedYes

ASJC Scopus subject areas

  • Bioengineering
  • Biomedical Engineering
  • General Materials Science
  • Condensed Matter Physics


Dive into the research topics of 'Temperature-sensitive nanocapsule for drug delivery'. Together they form a unique fingerprint.

Cite this