Temperature-sensitive nanocapsule for drug delivery

M. V. Suyetin; A. V. Vakhrushev

doi:10.1049/mnl.2010.0137

Temperature-sensitive nanocapsule for drug delivery

M. V. Suyetin^*, A. V. Vakhrushev

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

One of the most important applications of nanotechnology is to discover systems for targeted delivery of drugs, that is, designing nanocapsules (nanocontainers). Such nanocapsules have to take effect only in strictly localised areas to avoid drug action on healthy cells. The processes of doxorubicin storage and ejection by the carbon nanocapsule for drug delivery are studied by the method of molecular dynamics. The nanocapsule discussed consists of different nanotubes: (40,40), (10,10), (20,20) and (15,15) joint with each other by pentagonal and heptagonal rings. Nanocapsule stores doxorubicin molecule at normal human body temperature - 309.75K (36.6°C). The doxorubicin molecule is ejected owing to heating and further expansion of the gas inside the nanocapsule. The gas pushes the fullerene-piston, which ejects the doxorubicin molecule out of the nanocapsule. The temperature required for doxorubicin ejection is 316.75K (43.6°C). The temperature elevation can be reached with infrared radiation.

Original language	English (US)
Pages (from-to)	39-42
Number of pages	4
Journal	Micro and Nano Letters
Volume	6
Issue number	1
DOIs	https://doi.org/10.1049/mnl.2010.0137
State	Published - Jan 2011
Externally published	Yes

ASJC Scopus subject areas

Bioengineering
Biomedical Engineering
General Materials Science
Condensed Matter Physics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1049/mnl.2010.0137

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abstract = "One of the most important applications of nanotechnology is to discover systems for targeted delivery of drugs, that is, designing nanocapsules (nanocontainers). Such nanocapsules have to take effect only in strictly localised areas to avoid drug action on healthy cells. The processes of doxorubicin storage and ejection by the carbon nanocapsule for drug delivery are studied by the method of molecular dynamics. The nanocapsule discussed consists of different nanotubes: (40,40), (10,10), (20,20) and (15,15) joint with each other by pentagonal and heptagonal rings. Nanocapsule stores doxorubicin molecule at normal human body temperature - 309.75K (36.6°C). The doxorubicin molecule is ejected owing to heating and further expansion of the gas inside the nanocapsule. The gas pushes the fullerene-piston, which ejects the doxorubicin molecule out of the nanocapsule. The temperature required for doxorubicin ejection is 316.75K (43.6°C). The temperature elevation can be reached with infrared radiation.",

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Temperature-sensitive nanocapsule for drug delivery

Abstract

ASJC Scopus subject areas

UN SDGs

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