Testicular germ cell tumors in undescended testes: A report of five cases

We observed five cases of testicular tumor in patients with cryptorchidism. Case 1, a 27-year-old man with Down's syndrome was admitted to our hospital with the chief complaint of a left groin mass. The diagnosis was bilateral undescended testes and left testicular tumor. Left inguinal orchiectomy and right orchidopexy were performed and the pathological findings showed a seminoma of left testis (pT2). Case 2, a 38-year-old man with the complaint of lower abdominal swelling and pain was admitted to our hospital. CT and MRI showed a large intra-abdominal mass of unknown origin. Angiography confirmed that the mass had arisen from the left undescended testis. He was therefore referred to our department. The excision of abdominal mass was performed and the pathological findings showed a seminoma (pT4). Case 3, a 44-year-old man was admitted to his local hospital because of gastric ulcer. A right groin mass was detected by physical examination and testicular cancer was suspected. Right inguinal orchiectomy was performed and the pathological findings showed a seminoma (pT2). Case 4, a 27-year-old man, who had undergone orchidopexy on the right side 15 years earlier, was admitted to his local hospital because of right testicular cancer. Right inguinal orchiectomy was performed and the pathological findings showed a embryonal carcinoma and immature teratoma with syncytiotrophoblastic giant cells (pT2). He was referred to our hospital for adjuvant chemotherapy for metastases to the lung and para-aortic lymph nodes. Case 5, a 30-year-old man, who had undergone bilateral orchidopexy 19 years earlier, was admitted to our hospital because of right groin mass. Right orchiectomy was performed and pathological findings showed a yolk sac tumor with syncytiotrophoblastic giant cells (pT1). Among the 49 patients diagnosed with testicular cancer in our hospital during a period of approximately 20 years, 5 (10.2%) were cases of testicular cancer which had occurred in an undescended testis. A discussion of the relationship between testicular cancer and undescended testis is contained in this report.