The anticancer activity of an air-stable Pd(I)-NHC (NHC = N-heterocyclic carbene) dimer.

Thomas Scattolin; Enrica Bortolamiol; Stefano Palazzolo; Isabella Caligiuri; Tiziana Perin; Vincenzo Canzonieri; Nicola Demitri; Flavio Rizzolio; Luigi Cavallo; Busra Dereli; Manoj Vasisht Mane; Steven P. Nolan; Fabiano Visentin

doi:10.1039/d0cc03883k

The anticancer activity of an air-stable Pd(I)-NHC (NHC = N-heterocyclic carbene) dimer.

Thomas Scattolin, Enrica Bortolamiol, Stefano Palazzolo, Isabella Caligiuri, Tiziana Perin, Vincenzo Canzonieri, Nicola Demitri, Flavio Rizzolio, Luigi Cavallo, Busra Dereli, Manoj Vasisht Mane, Steven P. Nolan, Fabiano Visentin

Research output: Contribution to journal › Article › peer-review

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Abstract

A new dinuclear Pd(i) complex coordinating two bis(NHC) ligands revealed an unsuspected stability despite the unsaturation of the two metal centres. Even more surprisingly, the compound showed high and selective antiproliferative activity against different cancer cell lines and ovarian cancer tumoroids, and the mechanism of action was different from that of cisplatin.

Original language	English (US)
Journal	Chemical communications (Cambridge, England)
DOIs	https://doi.org/10.1039/d0cc03883k
State	Published - Sep 14 2020

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10.1039/d0cc03883k

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@article{79c101bb1ea54a3cb4c5da72bc8ed02e,

title = "The anticancer activity of an air-stable Pd(I)-NHC (NHC = N-heterocyclic carbene) dimer.",

abstract = "A new dinuclear Pd(i) complex coordinating two bis(NHC) ligands revealed an unsuspected stability despite the unsaturation of the two metal centres. Even more surprisingly, the compound showed high and selective antiproliferative activity against different cancer cell lines and ovarian cancer tumoroids, and the mechanism of action was different from that of cisplatin.",

author = "Thomas Scattolin and Enrica Bortolamiol and Stefano Palazzolo and Isabella Caligiuri and Tiziana Perin and Vincenzo Canzonieri and Nicola Demitri and Flavio Rizzolio and Luigi Cavallo and Busra Dereli and Mane, {Manoj Vasisht} and Nolan, {Steven P.} and Fabiano Visentin",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: F. R. is thankful to Fondazione AIRC per la Ricerca sul Cancro (Grant AIRC IG23566). For work carried out in Ghent, the UGent BOF and the Moonshot project D2M are gratefully acknowledged.",

year = "2020",

month = sep,

day = "14",

doi = "10.1039/d0cc03883k",

language = "English (US)",

journal = "Chemical communications (Cambridge, England)",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - The anticancer activity of an air-stable Pd(I)-NHC (NHC = N-heterocyclic carbene) dimer.

AU - Scattolin, Thomas

AU - Bortolamiol, Enrica

AU - Palazzolo, Stefano

AU - Caligiuri, Isabella

AU - Perin, Tiziana

AU - Canzonieri, Vincenzo

AU - Demitri, Nicola

AU - Rizzolio, Flavio

AU - Cavallo, Luigi

AU - Dereli, Busra

AU - Mane, Manoj Vasisht

AU - Nolan, Steven P.

AU - Visentin, Fabiano

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: F. R. is thankful to Fondazione AIRC per la Ricerca sul Cancro (Grant AIRC IG23566). For work carried out in Ghent, the UGent BOF and the Moonshot project D2M are gratefully acknowledged.

PY - 2020/9/14

Y1 - 2020/9/14

N2 - A new dinuclear Pd(i) complex coordinating two bis(NHC) ligands revealed an unsuspected stability despite the unsaturation of the two metal centres. Even more surprisingly, the compound showed high and selective antiproliferative activity against different cancer cell lines and ovarian cancer tumoroids, and the mechanism of action was different from that of cisplatin.

AB - A new dinuclear Pd(i) complex coordinating two bis(NHC) ligands revealed an unsuspected stability despite the unsaturation of the two metal centres. Even more surprisingly, the compound showed high and selective antiproliferative activity against different cancer cell lines and ovarian cancer tumoroids, and the mechanism of action was different from that of cisplatin.

UR - http://hdl.handle.net/10754/665175

UR - http://xlink.rsc.org/?DOI=D0CC03883K

U2 - 10.1039/d0cc03883k

DO - 10.1039/d0cc03883k

M3 - Article

C2 - 32926011

SN - 1359-7345

JO - Chemical communications (Cambridge, England)

JF - Chemical communications (Cambridge, England)

ER -

The anticancer activity of an air-stable Pd(I)-NHC (NHC = N-heterocyclic carbene) dimer.

Abstract

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CCDC 2006223: Experimental Crystal Structure Determination

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The anticancer activity of an air-stable Pd(I)-NHC (NHC = N-heterocyclic carbene) dimer.

Abstract

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CCDC 2006223: Experimental Crystal Structure Determination

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