TY - JOUR
T1 - The Arabidopsis homolog of human G3BP1 is a key regulator of stomatal and apoplastic immunity
AU - Abulfaraj, Aala A.
AU - Mariappan, Kiruthiga
AU - Bigeard, Jean
AU - Manickam, Prabhu
AU - Blilou, Ikram
AU - Guo, Xiujie
AU - Al-Babili, Salim
AU - Pflieger, Delphine
AU - Hirt, Heribert
AU - Rayapuram, Naganand
N1 - KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: This work was supported by the King Abdullah University of Science and Technology and Agence Nationale de la Recherche (ANR-2010-JCJC-1608). The Institute of Plant Sciences Paris-Saclay benefits from the support of the LabEx Saclay Plant Sciences (ANR-10-LABX-0040-SPS).
PY - 2018/5/31
Y1 - 2018/5/31
N2 - Mammalian Ras-GTPase–activating protein SH3-domain–binding proteins (G3BPs) are a highly conserved family of RNA-binding proteins that link kinase receptor-mediated signaling to RNA metabolism. Mammalian G3BP1 is a multifunctional protein that functions in viral immunity. Here, we show that the Arabidopsis thaliana homolog of human G3BP1 negatively regulates plant immunity. Arabidopsis g3bp1 mutants showed enhanced resistance to the virulent bacterial pathogen Pseudomonas syringae pv. tomato. Pathogen resistance was mediated in Atg3bp1 mutants by altered stomatal and apoplastic immunity. Atg3bp1 mutants restricted pathogen entry into stomates showing insensitivity to bacterial coronatine–mediated stomatal reopening. AtG3BP1 was identified as a negative regulator of defense responses, which correlated with moderate up-regulation of salicylic acid biosynthesis and signaling without growth penalty.
AB - Mammalian Ras-GTPase–activating protein SH3-domain–binding proteins (G3BPs) are a highly conserved family of RNA-binding proteins that link kinase receptor-mediated signaling to RNA metabolism. Mammalian G3BP1 is a multifunctional protein that functions in viral immunity. Here, we show that the Arabidopsis thaliana homolog of human G3BP1 negatively regulates plant immunity. Arabidopsis g3bp1 mutants showed enhanced resistance to the virulent bacterial pathogen Pseudomonas syringae pv. tomato. Pathogen resistance was mediated in Atg3bp1 mutants by altered stomatal and apoplastic immunity. Atg3bp1 mutants restricted pathogen entry into stomates showing insensitivity to bacterial coronatine–mediated stomatal reopening. AtG3BP1 was identified as a negative regulator of defense responses, which correlated with moderate up-regulation of salicylic acid biosynthesis and signaling without growth penalty.
UR - http://hdl.handle.net/10754/628011
UR - http://www.life-science-alliance.org/content/1/2/e201800046
UR - http://www.scopus.com/inward/record.url?scp=85057031321&partnerID=8YFLogxK
U2 - 10.26508/lsa.201800046
DO - 10.26508/lsa.201800046
M3 - Article
C2 - 30456348
SN - 2575-1077
VL - 1
SP - e201800046
JO - Life Science Alliance
JF - Life Science Alliance
IS - 2
ER -