The association of diabetes with risk of prostate cancer defined by clinical and molecular features

Xiaoshuang Feng, Mingyang Song, Mark A. Preston, Wenjie Ma, Yang Hu, Claire H. Pernar, Konrad H. Stopsack, Ericka M. Ebot, Benjamin C. Fu, Yiwen Zhang, Ni Li, Min Dai, Lydia Liu, Edward L. Giovannucci, Lorelei A. Mucci

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Background: To prospectively examine the association between diabetes and risk of prostate cancer defined by clinical and molecular features. Methods: A total of 49,392 men from the Health Professionals Follow-up Study (HPFS) were followed from 1986 to 2014. Data on self-reported diabetes were collected at baseline and updated biennially. Clinical features of prostate cancer included localised, advanced, lethal, low-grade, intermediate-grade, and high-grade. Molecular features included TMPRSS2: ERG and PTEN subtypes. Cox proportional hazards regression models were used to evaluate the association between diabetes and incidence of subtype-specific prostate cancer. Results: During 28 years of follow-up, we documented 6733 incident prostate cancer cases. Relative to men free from diabetes, men with diabetes had lower risks of total (HR: 0.82, 95% CI: 0.75–0.90), localised (HR: 0.82, 95% CI: 0.74–0.92), low-and intermediate-grade prostate cancer (HR: 0.77, 95% CI: 0.66–0.90; HR: 0.77, 95% CI: 0.65–0.91, respectively). For molecular subtypes, the HRs for ERG-negative and ERG-positive cases were 0.63 (0.42–0.95) and 0.72 (0.46–1.12); and for PTEN-intact and PTEN-loss cases were 0.69 (0.48–0.98) and 0.52 (0.19–1.41), respectively. Conclusion: Besides providing advanced evidence for the inverse association between diabetes and prostate cancer, this study is the first to report associations between diabetes and ERG/PTEN defined prostate cancers.
Original languageEnglish (US)
Pages (from-to)657-665
Number of pages9
JournalBritish Journal of Cancer
Issue number4
StatePublished - Aug 18 2020
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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