TY - JOUR
T1 - The Effects of Aerobic Exercise and Ginger Extract Loaded into Chitosan Nanoparticles on Atrial Natriuretic Peptide (ANP) Gene and Cardiac Histopathology in Rat Models of Myocardial Infarction
AU - Fallahzadeh, Vahid
AU - Taghian, Farzaneh
AU - Dehkordi, Khosro Jalali
N1 - KAUST Repository Item: Exported on 2023-05-24
Acknowledgements: This work was supported by King Abdullah University of Science and Technology (KAUST) and by the Singapore National Research Foundation (NRF-CRP14-2014-03). We gratefully thank the IT Research Computing Team and Supercomputing Laboratory at KAUST for computational and storage resources as well as precious assistance.
This publication acknowledges KAUST support, but has no KAUST affiliated authors.
PY - 2023/1/10
Y1 - 2023/1/10
N2 - Introduction: In this study, the effects of aerobic exercises and encapsulated ginger extract (GE) into chitosan nanoparticles (CNPs) were investigated on atrial natriuretic peptide (ANP) gene expression and cardiac histopathology in rat models of myocardial infarction. Methods: The 25 male rats were divided into five groups: Isop (85 mg/kg), Isop + CNPs, Isop + GE-CNPs, Isop + AE, and Isop + GE-CNPs + AE. The rats performed AE on a rodent treadmill five days per week for six weeks. GE-CNPs were gavaged to rats at a dose of 500 mg/kg for six weeks. After the end of the treatment period, the expression of ANP genes was carried out by Real-Time PCR. Results: Based on our findings, the highest amount of collagen deposition was in the heart tissue of patient groups and the patient group treated with chitosan nanoparticles (P
AB - Introduction: In this study, the effects of aerobic exercises and encapsulated ginger extract (GE) into chitosan nanoparticles (CNPs) were investigated on atrial natriuretic peptide (ANP) gene expression and cardiac histopathology in rat models of myocardial infarction. Methods: The 25 male rats were divided into five groups: Isop (85 mg/kg), Isop + CNPs, Isop + GE-CNPs, Isop + AE, and Isop + GE-CNPs + AE. The rats performed AE on a rodent treadmill five days per week for six weeks. GE-CNPs were gavaged to rats at a dose of 500 mg/kg for six weeks. After the end of the treatment period, the expression of ANP genes was carried out by Real-Time PCR. Results: Based on our findings, the highest amount of collagen deposition was in the heart tissue of patient groups and the patient group treated with chitosan nanoparticles (P
UR - http://hdl.handle.net/10754/691982
UR - http://www.scopus.com/inward/record.url?scp=85146277450&partnerID=8YFLogxK
U2 - 10.22100/jkh.v17i4.2801
DO - 10.22100/jkh.v17i4.2801
M3 - Article
SN - 1735-577X
VL - 17
SP - 34
EP - 43
JO - Journal of Knowledge and Health in Basic Medical Sciences
JF - Journal of Knowledge and Health in Basic Medical Sciences
IS - 4
ER -