The emerging link between cancer, metabolism, and circadian rhythms

Selma Masri, Paolo Sassone-Corsi

Research output: Contribution to journalArticlepeer-review

251 Scopus citations

Abstract

The circadian clock is a complex cellular mechanism that, through the control of diverse metabolic and gene expression pathways, governs a large array of cyclic physiological processes. Epidemiological and clinical data reveal a connection between the disruption of circadian rhythms and cancer that is supported by recent preclinical data. In addition, results from animal models and molecular studies underscore emerging links between cancer metabolism and the circadian clock. This has implications for therapeutic approaches, and we discuss the possible design of chronopharmacological strategies.
Original languageEnglish (US)
Pages (from-to)1795-1803
Number of pages9
JournalNature Medicine
Volume24
Issue number12
DOIs
StatePublished - Dec 6 2018
Externally publishedYes

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