TY - JOUR
T1 - The emerging link between cancer, metabolism, and circadian rhythms
AU - Masri, Selma
AU - Sassone-Corsi, Paolo
N1 - KAUST Repository Item: Exported on 2022-06-07
Acknowledgements: The Masri laboratory is supported by a K22 Transition Career Development Award through the National Cancer Institute (NCI), the Concern Foundation, and the V Foundation for Cancer Research. Work in the Sassone-Corsi laboratory is supported by NIH (National Institutes of Health), INSERM (Institut National de la Sante et la Recherche Medicale, France), and KAUST (King Abdullah University of Science and Technology, Saudi Arabia).
This publication acknowledges KAUST support, but has no KAUST affiliated authors.
PY - 2018/12/6
Y1 - 2018/12/6
N2 - The circadian clock is a complex cellular mechanism that, through the control of diverse metabolic and gene expression pathways, governs a large array of cyclic physiological processes. Epidemiological and clinical data reveal a connection between the disruption of circadian rhythms and cancer that is supported by recent preclinical data. In addition, results from animal models and molecular studies underscore emerging links between cancer metabolism and the circadian clock. This has implications for therapeutic approaches, and we discuss the possible design of chronopharmacological strategies.
AB - The circadian clock is a complex cellular mechanism that, through the control of diverse metabolic and gene expression pathways, governs a large array of cyclic physiological processes. Epidemiological and clinical data reveal a connection between the disruption of circadian rhythms and cancer that is supported by recent preclinical data. In addition, results from animal models and molecular studies underscore emerging links between cancer metabolism and the circadian clock. This has implications for therapeutic approaches, and we discuss the possible design of chronopharmacological strategies.
UR - http://hdl.handle.net/10754/678635
UR - http://www.nature.com/articles/s41591-018-0271-8
UR - http://www.scopus.com/inward/record.url?scp=85058048694&partnerID=8YFLogxK
U2 - 10.1038/s41591-018-0271-8
DO - 10.1038/s41591-018-0271-8
M3 - Article
C2 - 30523327
SN - 1546-170X
VL - 24
SP - 1795
EP - 1803
JO - Nature Medicine
JF - Nature Medicine
IS - 12
ER -
