The Global, Regional, and National Burden of Adult Lip, Oral, and Pharyngeal Cancer in 204 Countries and Territories

Oral GBD 2019 Lip; Amanda Ramos da Cunha; Kelly Compton; Rixing Xu; Rashmi Mishra; Mark Thomas Drangsholt; Jose Leopoldo Ferreira Antunes; Alexander R. Kerr; Alistair R. Acheson; Dan Lu; Lindsey E. Wallace; Jonathan M. Kocarnik; Weijia Fu; Frances E. Dean; Alyssa Pennini; Hannah Jacqueline Henrikson; Tahiya Alam; Emad Ababneh; Sherief Abd-Elsalam; Meriem Abdoun; Hassan Abidi; Hiwa Abubaker Ali; Eman Abu-Gharbieh; Tigist Demssew Adane; Isaac Yeboah Addo; Aqeel Ahmad; Sajjad Ahmad; Tarik Ahmed Rashid; Maxwell Akonde; Hanadi Al Hamad; Fares Alahdab; Yousef Alimohamadi; Vahid Alipour; Sadeq Ali Al-Maweri; Ubai Alsharif; Alireza Ansari-Moghaddam; Sumadi Lukman Anwar; Anayochukwu Edward Anyasodor; Jalal Arabloo; Aleksandr Y. Aravkin; Raphael Taiwo Aruleba; Malke Asaad; Tahira Ashraf; Seyyed Shamsadin Athari; Sameh Attia; Sina Azadnajafabad; Mohammadreza Azangou-Khyavy; Muhammad Badar; Nayereh Baghcheghi; Maciej Banach; Mainak Bardhan; Hiba Jawdat Barqawi; Nasir Z. Bashir; Azadeh Bashiri; Habib Benzian; Eduardo Bernabe; Devidas S. Bhagat; Vijayalakshmi S. Bhojaraja; Tone Bj�rge; Souad Bouaoud; Dejana Braithwaite; Nikolay Ivanovich Briko; Daniela Calina; Giulia Carreras; Promit Ananyo Chakraborty; Vijay Kumar Chattu; Akhilanand Chaurasia; Meng Xuan Chen; William C. S. Cho; Dinh-Toi Chu; Isaac Sunday Chukwu; Eunice Chung; Nat�lia Cruz-Martins; Omid Dadras; Xiaochen Dai; Lalit Dandona; Rakhi Dandona; Parnaz Daneshpajouhnejad; Reza Darvishi Cheshmeh Soltani; Aso Mohammad Darwesh; Sisay Abebe Debela; Meseret Derbew Molla; Fikadu Nugusu Dessalegn; Mostafa Dianati-Nasab; Lankamo Ena Digesa; Shilpi Gupta Dixit; Abhinav Dixit; Shirin Djalalinia; Iman El Sayed; Maha El Tantawi; Daniel Berhanie Enyew; Daniel Asfaw Erku; Rana Ezzeddini; Adeniyi Francis Fagbamigbe; Luca Falzone; Getahun Fetensa; Takeshi Fukumoto; Piyada Gaewkhiew; Silvano Gallus; Mesfin Gebrehiwot; Ahmad Ghashghaee; Paramjit Singh Gill; Mahaveer Golechha; Pouya Goleij; Ricardo Santiago Gomez; Giuseppe Gorini; Andre Luiz Sena Guimaraes; Bhawna Gupta; Sapna Gupta; Veer Bala Gupta; Vivek Kumar Gupta; Arvin Haj-Mirzaian; Esam S. Halboub; Rabih Halwani; Asif Hanif; Ninuk Hariyani; Mehdi Harorani; Hamidreza Hasani; Abbas M. Hassan; Soheil Hassanipour; Mohammed Bheser Hassen; Simon I. Hay; Khezar Hayat; Brenda Yuliana Herrera-Serna; Ramesh Holla; Nobuyuki Horita; Mehdi Hosseinzadeh; Salman Hussain; Olayinka Stephen Ilesanmi; Irena M. Ilic; Milena D. Ilic; Gaetano Isola; Abhishek Jaiswal; Chinmay T. Jani; Tahereh Javaheri; Umesh Jayarajah; Shubha Jayaram; Nitin Joseph; Vidya Kadashetti; Eswar Kandaswamy; Shama D. Karanth; Ibraheem M. Karaye; Joonas H. Kauppila; Harkiran Kaur; Mohammad Keykhaei; Yousef Saleh Khader; Himanshu Khajuria; Javad Khanali; Mahalaqua Nazli Khatib; Hamid Reza Khayat Kashani; Mohammad Amin Khazeei Tabari; Min Seo Kim; Farzad Kompani; Hamid Reza Koohestani; G. Anil Kumar; Om P. Kurmi; Carlo La Vecchia; Dharmesh Kumar Lal; Iv�n Landires; Savita Lasrado; Caterina Ledda; Yo Han Lee; Massimo Libra; Stephen S. Lim; Stefan Listl; Platon D. Lopukhov; Ahmad R. Mafi; Rashidul Alam Mahumud; Ahmad Azam Malik; Manu Raj Mathur; Sazan Qadir Maulud; Jitendra Kumar Meena; Entezar Mehrabi Nasab; Tomislav Mestrovic; Reza Mirfakhraie; Awoke Misganaw; Sanjeev Misra; Prasanna Mithra; Yousef Mohammad; Mokhtar Mohammadi; Esmaeil Mohammadi; Ali H. Mokdad; Mohammad Ali Moni; Paula Moraga; Shane Douglas Morrison; Hamid Reza Mozaffari; Sumaira Mubarik; Christopher J. L. Murray; Tapas Sadasivan Nair; Sreenivas Narasimha Swamy; Aparna Ichalangod Narayana; Hasan Nassereldine; Zuhair S. Natto; Biswa Prakash Nayak; Serban Mircea Negru; Haruna Asura Nggada; Hasti Nouraei; Virginia Nu�ez-Samudio; Bogdan Oancea; Andrew T. Olagunju; Ahmed Omar Bali; Alicia Padron-Monedero; Jagadish Rao Padubidri; Anamika Pandey; Shahina Pardhan; Jay Patel; Raffaele Pezzani; Zahra Zahid Piracha; Navid Rabiee; Venkatraman Radhakrishnan; Raghu Anekal Radhakrishnan; Amir Masoud Rahmani; Vahid Rahmanian; Chythra R. Rao; Sowmya J. Rao; Goura Kishor Rath; David Laith Rawaf; Salman Rawaf; Reza Rawassizadeh; Mohammad Sadegh Razeghinia; Nazila Rezaei; Negar Rezaei; Nima Rezaei; Aziz Rezapour; Abanoub Riad; Thomas J. Roberts; Esperanza Romero-Rodr�guez; Gholamreza Roshandel; Manjula S.; Chandan S. N.; Basema Saddik; Mohammad Reza Saeb; Umar Saeed; Mohsen Safaei; Maryam Sahebazzamani; Amirhossein Sahebkar; Amir Salek Farrokhi; Abdallah M. Samy; Milena M. Santric-Milicevic; Brijesh Sathian; Maheswar Satpathy; Mario �ekerija; Subramanian Senthilkumaran; Allen Seylani; Omid Shafaat; Hamid R. Shahsavari; Erfan Shamsoddin; Mequannent Melaku Sharew; Javad Sharifi-Rad; Jeevan K. Shetty; K. M. Shivakumar; Parnian Shobeiri; Seyed Afshin Shorofi; Sunil Shrestha; Sudeep K. Siddappa Malleshappa; Paramdeep Singh; Jasvinder A. Singh; Garima Singh; Dhirendra Narain Sinha; Yonatan Solomon; Muhammad Suleman; Rizwan Suliankatchi Abdulkader; Yasaman Taheri Abkenar; Iman M. Talaat; Ker-Kan Tan; Abdelghani Tbakhi; Arulmani Thiyagarajan; Amir Tiyuri; Marcos Roberto Tovani-Palone; Bhaskaran Unnikrishnan; Bay Vo; Simona Ruxandra Volovat; Cong Wang; Ronny Westerman; Nuwan Darshana Wickramasinghe; Hong Xiao; Chuanhua Yu; Deniz Yuce; Ismaeel Yunusa; Vesna Zadnik; Iman Zare; Zhi-Jiang Zhang; Mohammad Zoladl; Lisa M. Force; Fernando N. Hugo

doi:10.1001/jamaoncol.2023.2960

The Global, Regional, and National Burden of Adult Lip, Oral, and Pharyngeal Cancer in 204 Countries and Territories

Oral GBD 2019 Lip, Amanda Ramos da Cunha, Kelly Compton, Rixing Xu, Rashmi Mishra, Mark Thomas Drangsholt, Jose Leopoldo Ferreira Antunes, Alexander R. Kerr, Alistair R. Acheson, Dan Lu, Lindsey E. Wallace, Jonathan M. Kocarnik, Weijia Fu, Frances E. Dean, Alyssa Pennini, Hannah Jacqueline Henrikson, Tahiya Alam, Emad Ababneh, Sherief Abd-Elsalam, Meriem AbdounHassan Abidi, Hiwa Abubaker Ali, Eman Abu-Gharbieh, Tigist Demssew Adane, Isaac Yeboah Addo, Aqeel Ahmad, Sajjad Ahmad, Tarik Ahmed Rashid, Maxwell Akonde, Hanadi Al Hamad, Fares Alahdab, Yousef Alimohamadi, Vahid Alipour, Sadeq Ali Al-Maweri, Ubai Alsharif, Alireza Ansari-Moghaddam, Sumadi Lukman Anwar, Anayochukwu Edward Anyasodor, Jalal Arabloo, Aleksandr Y. Aravkin, Raphael Taiwo Aruleba, Malke Asaad, Tahira Ashraf, Seyyed Shamsadin Athari, Sameh Attia, Sina Azadnajafabad, Mohammadreza Azangou-Khyavy, Muhammad Badar, Nayereh Baghcheghi, Maciej Banach, Mainak Bardhan, Hiba Jawdat Barqawi, Nasir Z. Bashir, Azadeh Bashiri, Habib Benzian, Eduardo Bernabe, Devidas S. Bhagat, Vijayalakshmi S. Bhojaraja, Tone Bj�rge, Souad Bouaoud, Dejana Braithwaite, Nikolay Ivanovich Briko, Daniela Calina, Giulia Carreras, Promit Ananyo Chakraborty, Vijay Kumar Chattu, Akhilanand Chaurasia, Meng Xuan Chen, William C. S. Cho, Dinh-Toi Chu, Isaac Sunday Chukwu, Eunice Chung, Nat�lia Cruz-Martins, Omid Dadras, Xiaochen Dai, Lalit Dandona, Rakhi Dandona, Parnaz Daneshpajouhnejad, Reza Darvishi Cheshmeh Soltani, Aso Mohammad Darwesh, Sisay Abebe Debela, Meseret Derbew Molla, Fikadu Nugusu Dessalegn, Mostafa Dianati-Nasab, Lankamo Ena Digesa, Shilpi Gupta Dixit, Abhinav Dixit, Shirin Djalalinia, Iman El Sayed, Maha El Tantawi, Daniel Berhanie Enyew, Daniel Asfaw Erku, Rana Ezzeddini, Adeniyi Francis Fagbamigbe, Luca Falzone, Getahun Fetensa, Takeshi Fukumoto, Piyada Gaewkhiew, Silvano Gallus, Mesfin Gebrehiwot, Ahmad Ghashghaee, Paramjit Singh Gill, Mahaveer Golechha, Pouya Goleij, Ricardo Santiago Gomez, Giuseppe Gorini, Andre Luiz Sena Guimaraes, Bhawna Gupta, Sapna Gupta, Veer Bala Gupta, Vivek Kumar Gupta, Arvin Haj-Mirzaian, Esam S. Halboub, Rabih Halwani, Asif Hanif, Ninuk Hariyani, Mehdi Harorani, Hamidreza Hasani, Abbas M. Hassan, Soheil Hassanipour, Mohammed Bheser Hassen, Simon I. Hay, Khezar Hayat, Brenda Yuliana Herrera-Serna, Ramesh Holla, Nobuyuki Horita, Mehdi Hosseinzadeh, Salman Hussain, Olayinka Stephen Ilesanmi, Irena M. Ilic, Milena D. Ilic, Gaetano Isola, Abhishek Jaiswal, Chinmay T. Jani, Tahereh Javaheri, Umesh Jayarajah, Shubha Jayaram, Nitin Joseph, Vidya Kadashetti, Eswar Kandaswamy, Shama D. Karanth, Ibraheem M. Karaye, Joonas H. Kauppila, Harkiran Kaur, Mohammad Keykhaei, Yousef Saleh Khader, Himanshu Khajuria, Javad Khanali, Mahalaqua Nazli Khatib, Hamid Reza Khayat Kashani, Mohammad Amin Khazeei Tabari, Min Seo Kim, Farzad Kompani, Hamid Reza Koohestani, G. Anil Kumar, Om P. Kurmi, Carlo La Vecchia, Dharmesh Kumar Lal, Iv�n Landires, Savita Lasrado, Caterina Ledda, Yo Han Lee, Massimo Libra, Stephen S. Lim, Stefan Listl, Platon D. Lopukhov, Ahmad R. Mafi, Rashidul Alam Mahumud, Ahmad Azam Malik, Manu Raj Mathur, Sazan Qadir Maulud, Jitendra Kumar Meena, Entezar Mehrabi Nasab, Tomislav Mestrovic, Reza Mirfakhraie, Awoke Misganaw, Sanjeev Misra, Prasanna Mithra, Yousef Mohammad, Mokhtar Mohammadi, Esmaeil Mohammadi, Ali H. Mokdad, Mohammad Ali Moni, Paula Moraga, Shane Douglas Morrison, Hamid Reza Mozaffari, Sumaira Mubarik, Christopher J. L. Murray, Tapas Sadasivan Nair, Sreenivas Narasimha Swamy, Aparna Ichalangod Narayana, Hasan Nassereldine, Zuhair S. Natto, Biswa Prakash Nayak, Serban Mircea Negru, Haruna Asura Nggada, Hasti Nouraei, Virginia Nu�ez-Samudio, Bogdan Oancea, Andrew T. Olagunju, Ahmed Omar Bali, Alicia Padron-Monedero, Jagadish Rao Padubidri, Anamika Pandey, Shahina Pardhan, Jay Patel, Raffaele Pezzani, Zahra Zahid Piracha, Navid Rabiee, Venkatraman Radhakrishnan, Raghu Anekal Radhakrishnan, Amir Masoud Rahmani, Vahid Rahmanian, Chythra R. Rao, Sowmya J. Rao, Goura Kishor Rath, David Laith Rawaf, Salman Rawaf, Reza Rawassizadeh, Mohammad Sadegh Razeghinia, Nazila Rezaei, Negar Rezaei, Nima Rezaei, Aziz Rezapour, Abanoub Riad, Thomas J. Roberts, Esperanza Romero-Rodr�guez, Gholamreza Roshandel, Manjula S., Chandan S. N., Basema Saddik, Mohammad Reza Saeb, Umar Saeed, Mohsen Safaei, Maryam Sahebazzamani, Amirhossein Sahebkar, Amir Salek Farrokhi, Abdallah M. Samy, Milena M. Santric-Milicevic, Brijesh Sathian, Maheswar Satpathy, Mario �ekerija, Subramanian Senthilkumaran, Allen Seylani, Omid Shafaat, Hamid R. Shahsavari, Erfan Shamsoddin, Mequannent Melaku Sharew, Javad Sharifi-Rad, Jeevan K. Shetty, K. M. Shivakumar, Parnian Shobeiri, Seyed Afshin Shorofi, Sunil Shrestha, Sudeep K. Siddappa Malleshappa, Paramdeep Singh, Jasvinder A. Singh, Garima Singh, Dhirendra Narain Sinha, Yonatan Solomon, Muhammad Suleman, Rizwan Suliankatchi Abdulkader, Yasaman Taheri Abkenar, Iman M. Talaat, Ker-Kan Tan, Abdelghani Tbakhi, Arulmani Thiyagarajan, Amir Tiyuri, Marcos Roberto Tovani-Palone, Bhaskaran Unnikrishnan, Bay Vo, Simona Ruxandra Volovat, Cong Wang, Ronny Westerman, Nuwan Darshana Wickramasinghe, Hong Xiao, Chuanhua Yu, Deniz Yuce, Ismaeel Yunusa, Vesna Zadnik, Iman Zare, Zhi-Jiang Zhang, Mohammad Zoladl, Lisa M. Force, Fernando N. Hugo

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Importance: Lip, oral, and pharyngeal cancers are important contributors to cancer burden worldwide, and a comprehensive evaluation of their burden globally, regionally, and nationally is crucial for effective policy planning. Objective: To analyze the total and risk-attributable burden of lip and oral cavity cancer (LOC) and other pharyngeal cancer (OPC) for 204 countries and territories and by Socio-demographic Index (SDI) using 2019 Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study estimates. Evidence Review: The incidence, mortality, and disability-adjusted life years (DALYs) due to LOC and OPC from 1990 to 2019 were estimated using GBD 2019 methods. The GBD 2019 comparative risk assessment framework was used to estimate the proportion of deaths and DALYs for LOC and OPC attributable to smoking, tobacco, and alcohol consumption in 2019. Findings: In 2019, 370 000 (95% uncertainty interval [UI], 338 000-401 000) cases and 199 000 (95% UI, 181 000-217 000) deaths for LOC and 167 000 (95% UI, 153 000-180 000) cases and 114 000 (95% UI, 103 000-126 000) deaths for OPC were estimated to occur globally, contributing 5.5 million (95% UI, 5.0-6.0 million) and 3.2 million (95% UI, 2.9-3.6 million) DALYs, respectively. From 1990 to 2019, low-middle and low SDI regions consistently showed the highest age-standardized mortality rates due to LOC and OPC, while the high SDI strata exhibited age-standardized incidence rates decreasing for LOC and increasing for OPC. Globally in 2019, smoking had the greatest contribution to risk-attributable OPC deaths for both sexes (55.8% [95% UI, 49.2%-62.0%] of all OPC deaths in male individuals and 17.4% [95% UI, 13.8%-21.2%] of all OPC deaths in female individuals). Smoking and alcohol both contributed to substantial LOC deaths globally among male individuals (42.3% [95% UI, 35.2%-48.6%] and 40.2% [95% UI, 33.3%-46.8%] of all risk-attributable cancer deaths, respectively), while chewing tobacco contributed to the greatest attributable LOC deaths among female individuals (27.6% [95% UI, 21.5%-33.8%]), driven by high risk-attributable burden in South and Southeast Asia. Conclusions and Relevance: In this systematic analysis, disparities in LOC and OPC burden existed across the SDI spectrum, and a considerable percentage of burden was attributable to tobacco and alcohol use. These estimates can contribute to an understanding of the distribution and disparities in LOC and OPC burden globally and support cancer control planning efforts.

Original language	English (US)
Journal	JAMA Oncology
DOIs	https://doi.org/10.1001/jamaoncol.2023.2960
State	Published - Sep 7 2023

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1001/jamaoncol.2023.2960

Cite this

GBD 2019 Lip, O., Cunha, A. R. D., Compton, K., Xu, R., Mishra, R., Drangsholt, M. T., Antunes, J. L. F., Kerr, A. R., Acheson, A. R., Lu, D., Wallace, L. E., Kocarnik, J. M., Fu, W., Dean, F. E., Pennini, A., Henrikson, H. J., Alam, T., Ababneh, E., Abd-Elsalam, S., ... Hugo, F. N. (2023). The Global, Regional, and National Burden of Adult Lip, Oral, and Pharyngeal Cancer in 204 Countries and Territories. JAMA Oncology. https://doi.org/10.1001/jamaoncol.2023.2960

@article{284292184b2741bfa1f4cbeb961c33d8,

title = "The Global, Regional, and National Burden of Adult Lip, Oral, and Pharyngeal Cancer in 204 Countries and Territories",

abstract = "Importance: Lip, oral, and pharyngeal cancers are important contributors to cancer burden worldwide, and a comprehensive evaluation of their burden globally, regionally, and nationally is crucial for effective policy planning. Objective: To analyze the total and risk-attributable burden of lip and oral cavity cancer (LOC) and other pharyngeal cancer (OPC) for 204 countries and territories and by Socio-demographic Index (SDI) using 2019 Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study estimates. Evidence Review: The incidence, mortality, and disability-adjusted life years (DALYs) due to LOC and OPC from 1990 to 2019 were estimated using GBD 2019 methods. The GBD 2019 comparative risk assessment framework was used to estimate the proportion of deaths and DALYs for LOC and OPC attributable to smoking, tobacco, and alcohol consumption in 2019. Findings: In 2019, 370 000 (95% uncertainty interval [UI], 338 000-401 000) cases and 199 000 (95% UI, 181 000-217 000) deaths for LOC and 167 000 (95% UI, 153 000-180 000) cases and 114 000 (95% UI, 103 000-126 000) deaths for OPC were estimated to occur globally, contributing 5.5 million (95% UI, 5.0-6.0 million) and 3.2 million (95% UI, 2.9-3.6 million) DALYs, respectively. From 1990 to 2019, low-middle and low SDI regions consistently showed the highest age-standardized mortality rates due to LOC and OPC, while the high SDI strata exhibited age-standardized incidence rates decreasing for LOC and increasing for OPC. Globally in 2019, smoking had the greatest contribution to risk-attributable OPC deaths for both sexes (55.8% [95% UI, 49.2%-62.0%] of all OPC deaths in male individuals and 17.4% [95% UI, 13.8%-21.2%] of all OPC deaths in female individuals). Smoking and alcohol both contributed to substantial LOC deaths globally among male individuals (42.3% [95% UI, 35.2%-48.6%] and 40.2% [95% UI, 33.3%-46.8%] of all risk-attributable cancer deaths, respectively), while chewing tobacco contributed to the greatest attributable LOC deaths among female individuals (27.6% [95% UI, 21.5%-33.8%]), driven by high risk-attributable burden in South and Southeast Asia. Conclusions and Relevance: In this systematic analysis, disparities in LOC and OPC burden existed across the SDI spectrum, and a considerable percentage of burden was attributable to tobacco and alcohol use. These estimates can contribute to an understanding of the distribution and disparities in LOC and OPC burden globally and support cancer control planning efforts.",

author = "{GBD 2019 Lip}, Oral and Cunha, {Amanda Ramos da} and Kelly Compton and Rixing Xu and Rashmi Mishra and Drangsholt, {Mark Thomas} and Antunes, {Jose Leopoldo Ferreira} and Kerr, {Alexander R.} and Acheson, {Alistair R.} and Dan Lu and Wallace, {Lindsey E.} and Kocarnik, {Jonathan M.} and Weijia Fu and Dean, {Frances E.} and Alyssa Pennini and Henrikson, {Hannah Jacqueline} and Tahiya Alam and Emad Ababneh and Sherief Abd-Elsalam and Meriem Abdoun and Hassan Abidi and {Abubaker Ali}, Hiwa and Eman Abu-Gharbieh and Adane, {Tigist Demssew} and Addo, {Isaac Yeboah} and Aqeel Ahmad and Sajjad Ahmad and {Ahmed Rashid}, Tarik and Maxwell Akonde and {Al Hamad}, Hanadi and Fares Alahdab and Yousef Alimohamadi and Vahid Alipour and Al-Maweri, {Sadeq Ali} and Ubai Alsharif and Alireza Ansari-Moghaddam and Anwar, {Sumadi Lukman} and Anyasodor, {Anayochukwu Edward} and Jalal Arabloo and Aravkin, {Aleksandr Y.} and Aruleba, {Raphael Taiwo} and Malke Asaad and Tahira Ashraf and Athari, {Seyyed Shamsadin} and Sameh Attia and Sina Azadnajafabad and Mohammadreza Azangou-Khyavy and Muhammad Badar and Nayereh Baghcheghi and Maciej Banach and Mainak Bardhan and Barqawi, {Hiba Jawdat} and Bashir, {Nasir Z.} and Azadeh Bashiri and Habib Benzian and Eduardo Bernabe and Bhagat, {Devidas S.} and Bhojaraja, {Vijayalakshmi S.} and Tone Bj�rge and Souad Bouaoud and Dejana Braithwaite and Briko, {Nikolay Ivanovich} and Daniela Calina and Giulia Carreras and Chakraborty, {Promit Ananyo} and Chattu, {Vijay Kumar} and Akhilanand Chaurasia and Chen, {Meng Xuan} and Cho, {William C. S.} and Dinh-Toi Chu and Chukwu, {Isaac Sunday} and Eunice Chung and Nat�lia Cruz-Martins and Omid Dadras and Xiaochen Dai and Lalit Dandona and Rakhi Dandona and Parnaz Daneshpajouhnejad and {Darvishi Cheshmeh Soltani}, Reza and Darwesh, {Aso Mohammad} and Debela, {Sisay Abebe} and {Derbew Molla}, Meseret and Dessalegn, {Fikadu Nugusu} and Mostafa Dianati-Nasab and Digesa, {Lankamo Ena} and Dixit, {Shilpi Gupta} and Abhinav Dixit and Shirin Djalalinia and {El Sayed}, Iman and {El Tantawi}, Maha and Enyew, {Daniel Berhanie} and Erku, {Daniel Asfaw} and Rana Ezzeddini and Fagbamigbe, {Adeniyi Francis} and Luca Falzone and Getahun Fetensa and Takeshi Fukumoto and Piyada Gaewkhiew and Silvano Gallus and Mesfin Gebrehiwot and Ahmad Ghashghaee and Gill, {Paramjit Singh} and Mahaveer Golechha and Pouya Goleij and Gomez, {Ricardo Santiago} and Giuseppe Gorini and Guimaraes, {Andre Luiz Sena} and Bhawna Gupta and Sapna Gupta and Gupta, {Veer Bala} and Gupta, {Vivek Kumar} and Arvin Haj-Mirzaian and Halboub, {Esam S.} and Rabih Halwani and Asif Hanif and Ninuk Hariyani and Mehdi Harorani and Hamidreza Hasani and Hassan, {Abbas M.} and Soheil Hassanipour and Hassen, {Mohammed Bheser} and Hay, {Simon I.} and Khezar Hayat and Herrera-Serna, {Brenda Yuliana} and Ramesh Holla and Nobuyuki Horita and Mehdi Hosseinzadeh and Salman Hussain and Ilesanmi, {Olayinka Stephen} and Ilic, {Irena M.} and Ilic, {Milena D.} and Gaetano Isola and Abhishek Jaiswal and Jani, {Chinmay T.} and Tahereh Javaheri and Umesh Jayarajah and Shubha Jayaram and Nitin Joseph and Vidya Kadashetti and Eswar Kandaswamy and Karanth, {Shama D.} and Karaye, {Ibraheem M.} and Kauppila, {Joonas H.} and Harkiran Kaur and Mohammad Keykhaei and Khader, {Yousef Saleh} and Himanshu Khajuria and Javad Khanali and Khatib, {Mahalaqua Nazli} and {Khayat Kashani}, {Hamid Reza} and {Khazeei Tabari}, {Mohammad Amin} and Kim, {Min Seo} and Farzad Kompani and Koohestani, {Hamid Reza} and Kumar, {G. Anil} and Kurmi, {Om P.} and {La Vecchia}, Carlo and Lal, {Dharmesh Kumar} and Iv�n Landires and Savita Lasrado and Caterina Ledda and Lee, {Yo Han} and Massimo Libra and Lim, {Stephen S.} and Stefan Listl and Lopukhov, {Platon D.} and Mafi, {Ahmad R.} and Mahumud, {Rashidul Alam} and Malik, {Ahmad Azam} and Mathur, {Manu Raj} and Maulud, {Sazan Qadir} and Meena, {Jitendra Kumar} and {Mehrabi Nasab}, Entezar and Tomislav Mestrovic and Reza Mirfakhraie and Awoke Misganaw and Sanjeev Misra and Prasanna Mithra and Yousef Mohammad and Mokhtar Mohammadi and Esmaeil Mohammadi and Mokdad, {Ali H.} and Moni, {Mohammad Ali} and Paula Moraga and Morrison, {Shane Douglas} and Mozaffari, {Hamid Reza} and Sumaira Mubarik and Murray, {Christopher J. L.} and Nair, {Tapas Sadasivan} and {Narasimha Swamy}, Sreenivas and Narayana, {Aparna Ichalangod} and Hasan Nassereldine and Natto, {Zuhair S.} and Nayak, {Biswa Prakash} and Negru, {Serban Mircea} and Nggada, {Haruna Asura} and Hasti Nouraei and Virginia Nu�ez-Samudio and Bogdan Oancea and Olagunju, {Andrew T.} and {Omar Bali}, Ahmed and Alicia Padron-Monedero and Padubidri, {Jagadish Rao} and Anamika Pandey and Shahina Pardhan and Jay Patel and Raffaele Pezzani and Piracha, {Zahra Zahid} and Navid Rabiee and Venkatraman Radhakrishnan and Radhakrishnan, {Raghu Anekal} and Rahmani, {Amir Masoud} and Vahid Rahmanian and Rao, {Chythra R.} and Rao, {Sowmya J.} and Rath, {Goura Kishor} and Rawaf, {David Laith} and Salman Rawaf and Reza Rawassizadeh and Razeghinia, {Mohammad Sadegh} and Nazila Rezaei and Negar Rezaei and Nima Rezaei and Aziz Rezapour and Abanoub Riad and Roberts, {Thomas J.} and Esperanza Romero-Rodr�guez and Gholamreza Roshandel and Manjula S. and {S. N.}, Chandan and Basema Saddik and Saeb, {Mohammad Reza} and Umar Saeed and Mohsen Safaei and Maryam Sahebazzamani and Amirhossein Sahebkar and {Salek Farrokhi}, Amir and Samy, {Abdallah M.} and Santric-Milicevic, {Milena M.} and Brijesh Sathian and Maheswar Satpathy and Mario �ekerija and Subramanian Senthilkumaran and Allen Seylani and Omid Shafaat and Shahsavari, {Hamid R.} and Erfan Shamsoddin and Sharew, {Mequannent Melaku} and Javad Sharifi-Rad and Shetty, {Jeevan K.} and Shivakumar, {K. M.} and Parnian Shobeiri and Shorofi, {Seyed Afshin} and Sunil Shrestha and {Siddappa Malleshappa}, {Sudeep K.} and Paramdeep Singh and Singh, {Jasvinder A.} and Garima Singh and Sinha, {Dhirendra Narain} and Yonatan Solomon and Muhammad Suleman and {Suliankatchi Abdulkader}, Rizwan and {Taheri Abkenar}, Yasaman and Talaat, {Iman M.} and Ker-Kan Tan and Abdelghani Tbakhi and Arulmani Thiyagarajan and Amir Tiyuri and Tovani-Palone, {Marcos Roberto} and Bhaskaran Unnikrishnan and Bay Vo and Volovat, {Simona Ruxandra} and Cong Wang and Ronny Westerman and Wickramasinghe, {Nuwan Darshana} and Hong Xiao and Chuanhua Yu and Deniz Yuce and Ismaeel Yunusa and Vesna Zadnik and Iman Zare and Zhi-Jiang Zhang and Mohammad Zoladl and Force, {Lisa M.} and Hugo, {Fernando N.}",

note = "KAUST Repository Item: Exported on 2023-09-11 Acknowledgements: Financial support for Global Burden of Disease research was provided by the Bill & Melinda Gates Foundation.",

year = "2023",

month = sep,

day = "7",

doi = "10.1001/jamaoncol.2023.2960",

language = "English (US)",

journal = "JAMA Oncology",

issn = "2374-2437",

publisher = "American Medical Association",

}

GBD 2019 Lip, O, Cunha, ARD, Compton, K, Xu, R, Mishra, R, Drangsholt, MT, Antunes, JLF, Kerr, AR, Acheson, AR, Lu, D, Wallace, LE, Kocarnik, JM, Fu, W, Dean, FE, Pennini, A, Henrikson, HJ, Alam, T, Ababneh, E, Abd-Elsalam, S, Abdoun, M, Abidi, H, Abubaker Ali, H, Abu-Gharbieh, E, Adane, TD, Addo, IY, Ahmad, A, Ahmad, S, Ahmed Rashid, T, Akonde, M, Al Hamad, H, Alahdab, F, Alimohamadi, Y, Alipour, V, Al-Maweri, SA, Alsharif, U, Ansari-Moghaddam, A, Anwar, SL, Anyasodor, AE, Arabloo, J, Aravkin, AY, Aruleba, RT, Asaad, M, Ashraf, T, Athari, SS, Attia, S, Azadnajafabad, S, Azangou-Khyavy, M, Badar, M, Baghcheghi, N, Banach, M, Bardhan, M, Barqawi, HJ, Bashir, NZ, Bashiri, A, Benzian, H, Bernabe, E, Bhagat, DS, Bhojaraja, VS, Bj�rge, T, Bouaoud, S, Braithwaite, D, Briko, NI, Calina, D, Carreras, G, Chakraborty, PA, Chattu, VK, Chaurasia, A, Chen, MX, Cho, WCS, Chu, D-T, Chukwu, IS, Chung, E, Cruz-Martins, N, Dadras, O, Dai, X, Dandona, L, Dandona, R, Daneshpajouhnejad, P, Darvishi Cheshmeh Soltani, R, Darwesh, AM, Debela, SA, Derbew Molla, M, Dessalegn, FN, Dianati-Nasab, M, Digesa, LE, Dixit, SG, Dixit, A, Djalalinia, S, El Sayed, I, El Tantawi, M, Enyew, DB, Erku, DA, Ezzeddini, R, Fagbamigbe, AF, Falzone, L, Fetensa, G, Fukumoto, T, Gaewkhiew, P, Gallus, S, Gebrehiwot, M, Ghashghaee, A, Gill, PS, Golechha, M, Goleij, P, Gomez, RS, Gorini, G, Guimaraes, ALS, Gupta, B, Gupta, S, Gupta, VB, Gupta, VK, Haj-Mirzaian, A, Halboub, ES, Halwani, R, Hanif, A, Hariyani, N, Harorani, M, Hasani, H, Hassan, AM, Hassanipour, S, Hassen, MB, Hay, SI, Hayat, K, Herrera-Serna, BY, Holla, R, Horita, N, Hosseinzadeh, M, Hussain, S, Ilesanmi, OS, Ilic, IM, Ilic, MD, Isola, G, Jaiswal, A, Jani, CT, Javaheri, T, Jayarajah, U, Jayaram, S, Joseph, N, Kadashetti, V, Kandaswamy, E, Karanth, SD, Karaye, IM, Kauppila, JH, Kaur, H, Keykhaei, M, Khader, YS, Khajuria, H, Khanali, J, Khatib, MN, Khayat Kashani, HR, Khazeei Tabari, MA, Kim, MS, Kompani, F, Koohestani, HR, Kumar, GA, Kurmi, OP, La Vecchia, C, Lal, DK, Landires, I, Lasrado, S, Ledda, C, Lee, YH, Libra, M, Lim, SS, Listl, S, Lopukhov, PD, Mafi, AR, Mahumud, RA, Malik, AA, Mathur, MR, Maulud, SQ, Meena, JK, Mehrabi Nasab, E, Mestrovic, T, Mirfakhraie, R, Misganaw, A, Misra, S, Mithra, P, Mohammad, Y, Mohammadi, M, Mohammadi, E, Mokdad, AH, Moni, MA, Moraga, P, Morrison, SD, Mozaffari, HR, Mubarik, S, Murray, CJL, Nair, TS, Narasimha Swamy, S, Narayana, AI, Nassereldine, H, Natto, ZS, Nayak, BP, Negru, SM, Nggada, HA, Nouraei, H, Nu�ez-Samudio, V, Oancea, B, Olagunju, AT, Omar Bali, A, Padron-Monedero, A, Padubidri, JR, Pandey, A, Pardhan, S, Patel, J, Pezzani, R, Piracha, ZZ, Rabiee, N, Radhakrishnan, V, Radhakrishnan, RA, Rahmani, AM, Rahmanian, V, Rao, CR, Rao, SJ, Rath, GK, Rawaf, DL, Rawaf, S, Rawassizadeh, R, Razeghinia, MS, Rezaei, N, Rezaei, N, Rezaei, N, Rezapour, A, Riad, A, Roberts, TJ, Romero-Rodr�guez, E, Roshandel, G, S., M, S. N., C, Saddik, B, Saeb, MR, Saeed, U, Safaei, M, Sahebazzamani, M, Sahebkar, A, Salek Farrokhi, A, Samy, AM, Santric-Milicevic, MM, Sathian, B, Satpathy, M, �ekerija, M, Senthilkumaran, S, Seylani, A, Shafaat, O, Shahsavari, HR, Shamsoddin, E, Sharew, MM, Sharifi-Rad, J, Shetty, JK, Shivakumar, KM, Shobeiri, P, Shorofi, SA, Shrestha, S, Siddappa Malleshappa, SK, Singh, P, Singh, JA, Singh, G, Sinha, DN, Solomon, Y, Suleman, M, Suliankatchi Abdulkader, R, Taheri Abkenar, Y, Talaat, IM, Tan, K-K, Tbakhi, A, Thiyagarajan, A, Tiyuri, A, Tovani-Palone, MR, Unnikrishnan, B, Vo, B, Volovat, SR, Wang, C, Westerman, R, Wickramasinghe, ND, Xiao, H, Yu, C, Yuce, D, Yunusa, I, Zadnik, V, Zare, I, Zhang, Z-J, Zoladl, M, Force, LM & Hugo, FN 2023, 'The Global, Regional, and National Burden of Adult Lip, Oral, and Pharyngeal Cancer in 204 Countries and Territories', JAMA Oncology. https://doi.org/10.1001/jamaoncol.2023.2960

TY - JOUR

T1 - The Global, Regional, and National Burden of Adult Lip, Oral, and Pharyngeal Cancer in 204 Countries and Territories

AU - GBD 2019 Lip, Oral

AU - Cunha, Amanda Ramos da

AU - Compton, Kelly

AU - Xu, Rixing

AU - Mishra, Rashmi

AU - Drangsholt, Mark Thomas

AU - Antunes, Jose Leopoldo Ferreira

AU - Kerr, Alexander R.

AU - Acheson, Alistair R.

AU - Lu, Dan

AU - Wallace, Lindsey E.

AU - Kocarnik, Jonathan M.

AU - Fu, Weijia

AU - Dean, Frances E.

AU - Pennini, Alyssa

AU - Henrikson, Hannah Jacqueline

AU - Alam, Tahiya

AU - Ababneh, Emad

AU - Abd-Elsalam, Sherief

AU - Abdoun, Meriem

AU - Abidi, Hassan

AU - Abubaker Ali, Hiwa

AU - Abu-Gharbieh, Eman

AU - Adane, Tigist Demssew

AU - Addo, Isaac Yeboah

AU - Ahmad, Aqeel

AU - Ahmad, Sajjad

AU - Ahmed Rashid, Tarik

AU - Akonde, Maxwell

AU - Al Hamad, Hanadi

AU - Alahdab, Fares

AU - Alimohamadi, Yousef

AU - Alipour, Vahid

AU - Al-Maweri, Sadeq Ali

AU - Alsharif, Ubai

AU - Ansari-Moghaddam, Alireza

AU - Anwar, Sumadi Lukman

AU - Anyasodor, Anayochukwu Edward

AU - Arabloo, Jalal

AU - Aravkin, Aleksandr Y.

AU - Aruleba, Raphael Taiwo

AU - Asaad, Malke

AU - Ashraf, Tahira

AU - Athari, Seyyed Shamsadin

AU - Attia, Sameh

AU - Azadnajafabad, Sina

AU - Azangou-Khyavy, Mohammadreza

AU - Badar, Muhammad

AU - Baghcheghi, Nayereh

AU - Banach, Maciej

AU - Bardhan, Mainak

AU - Barqawi, Hiba Jawdat

AU - Bashir, Nasir Z.

AU - Bashiri, Azadeh

AU - Benzian, Habib

AU - Bernabe, Eduardo

AU - Bhagat, Devidas S.

AU - Bhojaraja, Vijayalakshmi S.

AU - Bj�rge, Tone

AU - Bouaoud, Souad

AU - Braithwaite, Dejana

AU - Briko, Nikolay Ivanovich

AU - Calina, Daniela

AU - Carreras, Giulia

AU - Chakraborty, Promit Ananyo

AU - Chattu, Vijay Kumar

AU - Chaurasia, Akhilanand

AU - Chen, Meng Xuan

AU - Cho, William C. S.

AU - Chu, Dinh-Toi

AU - Chukwu, Isaac Sunday

AU - Chung, Eunice

AU - Cruz-Martins, Nat�lia

AU - Dadras, Omid

AU - Dai, Xiaochen

AU - Dandona, Lalit

AU - Dandona, Rakhi

AU - Daneshpajouhnejad, Parnaz

AU - Darvishi Cheshmeh Soltani, Reza

AU - Darwesh, Aso Mohammad

AU - Debela, Sisay Abebe

AU - Derbew Molla, Meseret

AU - Dessalegn, Fikadu Nugusu

AU - Dianati-Nasab, Mostafa

AU - Digesa, Lankamo Ena

AU - Dixit, Shilpi Gupta

AU - Dixit, Abhinav

AU - Djalalinia, Shirin

AU - El Sayed, Iman

AU - El Tantawi, Maha

AU - Enyew, Daniel Berhanie

AU - Erku, Daniel Asfaw

AU - Ezzeddini, Rana

AU - Fagbamigbe, Adeniyi Francis

AU - Falzone, Luca

AU - Fetensa, Getahun

AU - Fukumoto, Takeshi

AU - Gaewkhiew, Piyada

AU - Gallus, Silvano

AU - Gebrehiwot, Mesfin

AU - Ghashghaee, Ahmad

AU - Gill, Paramjit Singh

AU - Golechha, Mahaveer

AU - Goleij, Pouya

AU - Gomez, Ricardo Santiago

AU - Gorini, Giuseppe

AU - Guimaraes, Andre Luiz Sena

AU - Gupta, Bhawna

AU - Gupta, Sapna

AU - Gupta, Veer Bala

AU - Gupta, Vivek Kumar

AU - Haj-Mirzaian, Arvin

AU - Halboub, Esam S.

AU - Halwani, Rabih

AU - Hanif, Asif

AU - Hariyani, Ninuk

AU - Harorani, Mehdi

AU - Hasani, Hamidreza

AU - Hassan, Abbas M.

AU - Hassanipour, Soheil

AU - Hassen, Mohammed Bheser

AU - Hay, Simon I.

AU - Hayat, Khezar

AU - Herrera-Serna, Brenda Yuliana

AU - Holla, Ramesh

AU - Horita, Nobuyuki

AU - Hosseinzadeh, Mehdi

AU - Hussain, Salman

AU - Ilesanmi, Olayinka Stephen

AU - Ilic, Irena M.

AU - Ilic, Milena D.

AU - Isola, Gaetano

AU - Jaiswal, Abhishek

AU - Jani, Chinmay T.

AU - Javaheri, Tahereh

AU - Jayarajah, Umesh

AU - Jayaram, Shubha

AU - Joseph, Nitin

AU - Kadashetti, Vidya

AU - Kandaswamy, Eswar

AU - Karanth, Shama D.

AU - Karaye, Ibraheem M.

AU - Kauppila, Joonas H.

AU - Kaur, Harkiran

AU - Keykhaei, Mohammad

AU - Khader, Yousef Saleh

AU - Khajuria, Himanshu

AU - Khanali, Javad

AU - Khatib, Mahalaqua Nazli

AU - Khayat Kashani, Hamid Reza

AU - Khazeei Tabari, Mohammad Amin

AU - Kim, Min Seo

AU - Kompani, Farzad

AU - Koohestani, Hamid Reza

AU - Kumar, G. Anil

AU - Kurmi, Om P.

AU - La Vecchia, Carlo

AU - Lal, Dharmesh Kumar

AU - Landires, Iv�n

AU - Lasrado, Savita

AU - Ledda, Caterina

AU - Lee, Yo Han

AU - Libra, Massimo

AU - Lim, Stephen S.

AU - Listl, Stefan

AU - Lopukhov, Platon D.

AU - Mafi, Ahmad R.

AU - Mahumud, Rashidul Alam

AU - Malik, Ahmad Azam

AU - Mathur, Manu Raj

AU - Maulud, Sazan Qadir

AU - Meena, Jitendra Kumar

AU - Mehrabi Nasab, Entezar

AU - Mestrovic, Tomislav

AU - Mirfakhraie, Reza

AU - Misganaw, Awoke

AU - Misra, Sanjeev

AU - Mithra, Prasanna

AU - Mohammad, Yousef

AU - Mohammadi, Mokhtar

AU - Mohammadi, Esmaeil

AU - Mokdad, Ali H.

AU - Moni, Mohammad Ali

AU - Moraga, Paula

AU - Morrison, Shane Douglas

AU - Mozaffari, Hamid Reza

AU - Mubarik, Sumaira

AU - Murray, Christopher J. L.

AU - Nair, Tapas Sadasivan

AU - Narasimha Swamy, Sreenivas

AU - Narayana, Aparna Ichalangod

AU - Nassereldine, Hasan

AU - Natto, Zuhair S.

AU - Nayak, Biswa Prakash

AU - Negru, Serban Mircea

AU - Nggada, Haruna Asura

AU - Nouraei, Hasti

AU - Nu�ez-Samudio, Virginia

AU - Oancea, Bogdan

AU - Olagunju, Andrew T.

AU - Omar Bali, Ahmed

AU - Padron-Monedero, Alicia

AU - Padubidri, Jagadish Rao

AU - Pandey, Anamika

AU - Pardhan, Shahina

AU - Patel, Jay

AU - Pezzani, Raffaele

AU - Piracha, Zahra Zahid

AU - Rabiee, Navid

AU - Radhakrishnan, Venkatraman

AU - Radhakrishnan, Raghu Anekal

AU - Rahmani, Amir Masoud

AU - Rahmanian, Vahid

AU - Rao, Chythra R.

AU - Rao, Sowmya J.

AU - Rath, Goura Kishor

AU - Rawaf, David Laith

AU - Rawaf, Salman

AU - Rawassizadeh, Reza

AU - Razeghinia, Mohammad Sadegh

AU - Rezaei, Nazila

AU - Rezaei, Negar

AU - Rezaei, Nima

AU - Rezapour, Aziz

AU - Riad, Abanoub

AU - Roberts, Thomas J.

AU - Romero-Rodr�guez, Esperanza

AU - Roshandel, Gholamreza

AU - S., Manjula

AU - S. N., Chandan

AU - Saddik, Basema

AU - Saeb, Mohammad Reza

AU - Saeed, Umar

AU - Safaei, Mohsen

AU - Sahebazzamani, Maryam

AU - Sahebkar, Amirhossein

AU - Salek Farrokhi, Amir

AU - Samy, Abdallah M.

AU - Santric-Milicevic, Milena M.

AU - Sathian, Brijesh

AU - Satpathy, Maheswar

AU - �ekerija, Mario

AU - Senthilkumaran, Subramanian

AU - Seylani, Allen

AU - Shafaat, Omid

AU - Shahsavari, Hamid R.

AU - Shamsoddin, Erfan

AU - Sharew, Mequannent Melaku

AU - Sharifi-Rad, Javad

AU - Shetty, Jeevan K.

AU - Shivakumar, K. M.

AU - Shobeiri, Parnian

AU - Shorofi, Seyed Afshin

AU - Shrestha, Sunil

AU - Siddappa Malleshappa, Sudeep K.

AU - Singh, Paramdeep

AU - Singh, Jasvinder A.

AU - Singh, Garima

AU - Sinha, Dhirendra Narain

AU - Solomon, Yonatan

AU - Suleman, Muhammad

AU - Suliankatchi Abdulkader, Rizwan

AU - Taheri Abkenar, Yasaman

AU - Talaat, Iman M.

AU - Tan, Ker-Kan

AU - Tbakhi, Abdelghani

AU - Thiyagarajan, Arulmani

AU - Tiyuri, Amir

AU - Tovani-Palone, Marcos Roberto

AU - Unnikrishnan, Bhaskaran

AU - Vo, Bay

AU - Volovat, Simona Ruxandra

AU - Wang, Cong

AU - Westerman, Ronny

AU - Wickramasinghe, Nuwan Darshana

AU - Xiao, Hong

AU - Yu, Chuanhua

AU - Yuce, Deniz

AU - Yunusa, Ismaeel

AU - Zadnik, Vesna

AU - Zare, Iman

AU - Zhang, Zhi-Jiang

AU - Zoladl, Mohammad

AU - Force, Lisa M.

AU - Hugo, Fernando N.

N1 - KAUST Repository Item: Exported on 2023-09-11 Acknowledgements: Financial support for Global Burden of Disease research was provided by the Bill & Melinda Gates Foundation.

PY - 2023/9/7

Y1 - 2023/9/7

N2 - Importance: Lip, oral, and pharyngeal cancers are important contributors to cancer burden worldwide, and a comprehensive evaluation of their burden globally, regionally, and nationally is crucial for effective policy planning. Objective: To analyze the total and risk-attributable burden of lip and oral cavity cancer (LOC) and other pharyngeal cancer (OPC) for 204 countries and territories and by Socio-demographic Index (SDI) using 2019 Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study estimates. Evidence Review: The incidence, mortality, and disability-adjusted life years (DALYs) due to LOC and OPC from 1990 to 2019 were estimated using GBD 2019 methods. The GBD 2019 comparative risk assessment framework was used to estimate the proportion of deaths and DALYs for LOC and OPC attributable to smoking, tobacco, and alcohol consumption in 2019. Findings: In 2019, 370 000 (95% uncertainty interval [UI], 338 000-401 000) cases and 199 000 (95% UI, 181 000-217 000) deaths for LOC and 167 000 (95% UI, 153 000-180 000) cases and 114 000 (95% UI, 103 000-126 000) deaths for OPC were estimated to occur globally, contributing 5.5 million (95% UI, 5.0-6.0 million) and 3.2 million (95% UI, 2.9-3.6 million) DALYs, respectively. From 1990 to 2019, low-middle and low SDI regions consistently showed the highest age-standardized mortality rates due to LOC and OPC, while the high SDI strata exhibited age-standardized incidence rates decreasing for LOC and increasing for OPC. Globally in 2019, smoking had the greatest contribution to risk-attributable OPC deaths for both sexes (55.8% [95% UI, 49.2%-62.0%] of all OPC deaths in male individuals and 17.4% [95% UI, 13.8%-21.2%] of all OPC deaths in female individuals). Smoking and alcohol both contributed to substantial LOC deaths globally among male individuals (42.3% [95% UI, 35.2%-48.6%] and 40.2% [95% UI, 33.3%-46.8%] of all risk-attributable cancer deaths, respectively), while chewing tobacco contributed to the greatest attributable LOC deaths among female individuals (27.6% [95% UI, 21.5%-33.8%]), driven by high risk-attributable burden in South and Southeast Asia. Conclusions and Relevance: In this systematic analysis, disparities in LOC and OPC burden existed across the SDI spectrum, and a considerable percentage of burden was attributable to tobacco and alcohol use. These estimates can contribute to an understanding of the distribution and disparities in LOC and OPC burden globally and support cancer control planning efforts.

AB - Importance: Lip, oral, and pharyngeal cancers are important contributors to cancer burden worldwide, and a comprehensive evaluation of their burden globally, regionally, and nationally is crucial for effective policy planning. Objective: To analyze the total and risk-attributable burden of lip and oral cavity cancer (LOC) and other pharyngeal cancer (OPC) for 204 countries and territories and by Socio-demographic Index (SDI) using 2019 Global Burden of Diseases, Injuries, and Risk Factors (GBD) Study estimates. Evidence Review: The incidence, mortality, and disability-adjusted life years (DALYs) due to LOC and OPC from 1990 to 2019 were estimated using GBD 2019 methods. The GBD 2019 comparative risk assessment framework was used to estimate the proportion of deaths and DALYs for LOC and OPC attributable to smoking, tobacco, and alcohol consumption in 2019. Findings: In 2019, 370 000 (95% uncertainty interval [UI], 338 000-401 000) cases and 199 000 (95% UI, 181 000-217 000) deaths for LOC and 167 000 (95% UI, 153 000-180 000) cases and 114 000 (95% UI, 103 000-126 000) deaths for OPC were estimated to occur globally, contributing 5.5 million (95% UI, 5.0-6.0 million) and 3.2 million (95% UI, 2.9-3.6 million) DALYs, respectively. From 1990 to 2019, low-middle and low SDI regions consistently showed the highest age-standardized mortality rates due to LOC and OPC, while the high SDI strata exhibited age-standardized incidence rates decreasing for LOC and increasing for OPC. Globally in 2019, smoking had the greatest contribution to risk-attributable OPC deaths for both sexes (55.8% [95% UI, 49.2%-62.0%] of all OPC deaths in male individuals and 17.4% [95% UI, 13.8%-21.2%] of all OPC deaths in female individuals). Smoking and alcohol both contributed to substantial LOC deaths globally among male individuals (42.3% [95% UI, 35.2%-48.6%] and 40.2% [95% UI, 33.3%-46.8%] of all risk-attributable cancer deaths, respectively), while chewing tobacco contributed to the greatest attributable LOC deaths among female individuals (27.6% [95% UI, 21.5%-33.8%]), driven by high risk-attributable burden in South and Southeast Asia. Conclusions and Relevance: In this systematic analysis, disparities in LOC and OPC burden existed across the SDI spectrum, and a considerable percentage of burden was attributable to tobacco and alcohol use. These estimates can contribute to an understanding of the distribution and disparities in LOC and OPC burden globally and support cancer control planning efforts.

UR - http://hdl.handle.net/10754/694277

UR - https://jamanetwork.com/journals/jamaoncology/fullarticle/2809272

U2 - 10.1001/jamaoncol.2023.2960

DO - 10.1001/jamaoncol.2023.2960

M3 - Article

C2 - 37676656

SN - 2374-2437

JO - JAMA Oncology

JF - JAMA Oncology

ER -

The Global, Regional, and National Burden of Adult Lip, Oral, and Pharyngeal Cancer in 204 Countries and Territories

Abstract

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this