TY - JOUR
T1 - The increase in cyclic-AMP levels elicited by vasoactive intestinal peptide (VIP) in mouse cerebral cortical slices is potentiated by ergot alkaloids
AU - Magistretti, Pierre J.
AU - Hof, Patrick
AU - Schorderet, Michel
PY - 1984
Y1 - 1984
N2 - We have recently observed that noradrenaline potentiates, via the activation of specific α-receptors, the stimulatory effects of vasoactive intestinal peptide on cyclic-AMP levels. We report here that certain ergot derivatives of the ergopeptine class, such as bromocriptine, ergotamine and codergocrine known to interact with alpha-adrenergic receptors, will also potentiate the effects of VIP on cyclic-AMP levels, without increasing directly the levels of the cyclic nucleotide. To our knowledge, these results demonstrate for the first time the existence of an interaction between a neuropeptide and ergot alkaloids within the cerebral cortex.
AB - We have recently observed that noradrenaline potentiates, via the activation of specific α-receptors, the stimulatory effects of vasoactive intestinal peptide on cyclic-AMP levels. We report here that certain ergot derivatives of the ergopeptine class, such as bromocriptine, ergotamine and codergocrine known to interact with alpha-adrenergic receptors, will also potentiate the effects of VIP on cyclic-AMP levels, without increasing directly the levels of the cyclic nucleotide. To our knowledge, these results demonstrate for the first time the existence of an interaction between a neuropeptide and ergot alkaloids within the cerebral cortex.
UR - http://www.scopus.com/inward/record.url?scp=0021714118&partnerID=8YFLogxK
U2 - 10.1016/0197-0186(84)90006-8
DO - 10.1016/0197-0186(84)90006-8
M3 - Article
AN - SCOPUS:0021714118
SN - 0197-0186
VL - 6
SP - 751
EP - 753
JO - Neurochemistry International
JF - Neurochemistry International
IS - 6
ER -