The intracellular region of Notch ligands: Does the tail make the difference?

Alessandro Pintar; Alfredo De Biasio; Matija Popovic; Neli Ivanova; Sándor Pongor

doi:10.1186/1745-6150-2-19

The intracellular region of Notch ligands: Does the tail make the difference?

Alessandro Pintar, Alfredo De Biasio, Matija Popovic, Neli Ivanova, Sándor Pongor

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

The cytoplasmic tail of Notch ligands drives endocytosis, mediates association with proteins implicated in the organization of cell-cell junctions and, through regulated intra-membrane proteolysis, is released from the membrane as a signaling fragment. We survey these findings and discuss the role of Notch ligands intracellular region in bidirectional signaling and possibly in signal modulation in mammals. © 2007 Pintar et al; licensee BioMed Central Ltd.

Original language	English (US)
Journal	Biology Direct
Volume	2
DOIs	https://doi.org/10.1186/1745-6150-2-19
State	Published - Jul 10 2007
Externally published	Yes

ASJC Scopus subject areas

General Agricultural and Biological Sciences
General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1186/1745-6150-2-19

Cite this

@article{d4e615091fc74c9fa5a65562ffd1d49a,

title = "The intracellular region of Notch ligands: Does the tail make the difference?",

abstract = "The cytoplasmic tail of Notch ligands drives endocytosis, mediates association with proteins implicated in the organization of cell-cell junctions and, through regulated intra-membrane proteolysis, is released from the membrane as a signaling fragment. We survey these findings and discuss the role of Notch ligands intracellular region in bidirectional signaling and possibly in signal modulation in mammals. {\textcopyright} 2007 Pintar et al; licensee BioMed Central Ltd.",

author = "Alessandro Pintar and {De Biasio}, Alfredo and Matija Popovic and Neli Ivanova and S{\'a}ndor Pongor",

note = "Generated from Scopus record by KAUST IRTS on 2022-09-13",

year = "2007",

month = jul,

day = "10",

doi = "10.1186/1745-6150-2-19",

language = "English (US)",

volume = "2",

journal = "Biology Direct",