The novel Cer-like protein Caronte mediates the establishment of embryonic left-right asymmetry

Concepción Rodríguez Esteban; Javier Capdevila; Aris N. Economides; Jaime Pascual; Ángel Ortiz; Juan Carlos Izpisúa Belmonte

doi:10.1038/45738

The novel Cer-like protein Caronte mediates the establishment of embryonic left-right asymmetry

Concepción Rodríguez Esteban, Javier Capdevila, Aris N. Economides, Jaime Pascual, Ángel Ortiz, Juan Carlos Izpisúa Belmonte

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185 Scopus citations

Abstract

In the chick embryo, left-right asymmetric patterns of gene expression in the lateral plate mesoderm are initiated by signals located in and around Hensen's node. Here we show that Caronte (Car), a secreted protein encoded by a member of the Cerberus/Dan gene family, mediates the Sonic hedgehog (Shh)- dependent induction of left-specific genes in the lateral plate mesoderm. Car is induced by Shh and repressed by fibroblast growth factor-8 (FGF-8). Car activates the expression of Nodal by antagonizing a repressive activity of bone morphogenic proteins (BMPs). Our results define a complex network of antagonistic molecular interactions between Activin, FGF-8, Lefty-1, Nodal, BMPs and Car that cooperate to control left-right asymmetry in the chick embryo.

Original language	English (US)
Pages (from-to)	243-251
Number of pages	9
Journal	NATURE
Volume	401
Issue number	6750
DOIs	https://doi.org/10.1038/45738
State	Published - Sep 16 1999
Externally published	Yes

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title = "The novel Cer-like protein Caronte mediates the establishment of embryonic left-right asymmetry",

abstract = "In the chick embryo, left-right asymmetric patterns of gene expression in the lateral plate mesoderm are initiated by signals located in and around Hensen's node. Here we show that Caronte (Car), a secreted protein encoded by a member of the Cerberus/Dan gene family, mediates the Sonic hedgehog (Shh)- dependent induction of left-specific genes in the lateral plate mesoderm. Car is induced by Shh and repressed by fibroblast growth factor-8 (FGF-8). Car activates the expression of Nodal by antagonizing a repressive activity of bone morphogenic proteins (BMPs). Our results define a complex network of antagonistic molecular interactions between Activin, FGF-8, Lefty-1, Nodal, BMPs and Car that cooperate to control left-right asymmetry in the chick embryo.",

author = "Esteban, {Concepci{\'o}n Rodr{\'i}guez} and Javier Capdevila and Economides, {Aris N.} and Jaime Pascual and {\'A}ngel Ortiz and {Izpis{\'u}a Belmonte}, {Juan Carlos}",

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T1 - The novel Cer-like protein Caronte mediates the establishment of embryonic left-right asymmetry

AU - Esteban, Concepción Rodríguez

AU - Capdevila, Javier

AU - Economides, Aris N.

AU - Pascual, Jaime

AU - Ortiz, Ángel

AU - Izpisúa Belmonte, Juan Carlos

PY - 1999/9/16

Y1 - 1999/9/16

N2 - In the chick embryo, left-right asymmetric patterns of gene expression in the lateral plate mesoderm are initiated by signals located in and around Hensen's node. Here we show that Caronte (Car), a secreted protein encoded by a member of the Cerberus/Dan gene family, mediates the Sonic hedgehog (Shh)- dependent induction of left-specific genes in the lateral plate mesoderm. Car is induced by Shh and repressed by fibroblast growth factor-8 (FGF-8). Car activates the expression of Nodal by antagonizing a repressive activity of bone morphogenic proteins (BMPs). Our results define a complex network of antagonistic molecular interactions between Activin, FGF-8, Lefty-1, Nodal, BMPs and Car that cooperate to control left-right asymmetry in the chick embryo.

AB - In the chick embryo, left-right asymmetric patterns of gene expression in the lateral plate mesoderm are initiated by signals located in and around Hensen's node. Here we show that Caronte (Car), a secreted protein encoded by a member of the Cerberus/Dan gene family, mediates the Sonic hedgehog (Shh)- dependent induction of left-specific genes in the lateral plate mesoderm. Car is induced by Shh and repressed by fibroblast growth factor-8 (FGF-8). Car activates the expression of Nodal by antagonizing a repressive activity of bone morphogenic proteins (BMPs). Our results define a complex network of antagonistic molecular interactions between Activin, FGF-8, Lefty-1, Nodal, BMPs and Car that cooperate to control left-right asymmetry in the chick embryo.

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The novel Cer-like protein Caronte mediates the establishment of embryonic left-right asymmetry

Abstract

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