TY - JOUR
T1 - The role of TGFβs and Sox9 during limb chondrogenesis
AU - Kawakami, Yasuhiko
AU - Rodriguez-León, Joaquín
AU - Belmonte, Juan Carlos Izpisúa
PY - 2006/12
Y1 - 2006/12
N2 - The majority of the skeletal elements, except the flat bones of the skull, are formed by endochondral ossification, in which cartilage is replaced by bone. The formation of cartilage is a multi-step process termed chondrogenesis, during which undifferentiated mesenchymal cells condense and undergo differentiation towards chondrocytes. Notwithstanding recent advances, our knowledge of the detailed mechanisms implicated in cartilage and bone formation is still scarce. Recent genetic, cellular and biochemical studies have highlighted the importance of TGFβ signaling and the activity of the transcription factor Sox9 during the early stages of vertebrate limb chondrogenesis.
AB - The majority of the skeletal elements, except the flat bones of the skull, are formed by endochondral ossification, in which cartilage is replaced by bone. The formation of cartilage is a multi-step process termed chondrogenesis, during which undifferentiated mesenchymal cells condense and undergo differentiation towards chondrocytes. Notwithstanding recent advances, our knowledge of the detailed mechanisms implicated in cartilage and bone formation is still scarce. Recent genetic, cellular and biochemical studies have highlighted the importance of TGFβ signaling and the activity of the transcription factor Sox9 during the early stages of vertebrate limb chondrogenesis.
UR - http://www.scopus.com/inward/record.url?scp=33750612500&partnerID=8YFLogxK
U2 - 10.1016/j.ceb.2006.10.007
DO - 10.1016/j.ceb.2006.10.007
M3 - Review article
C2 - 17049221
AN - SCOPUS:33750612500
SN - 0955-0674
VL - 18
SP - 723
EP - 729
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 6
ER -