The senescence-associated secretory phenotype as a driver of tumor growth: does G3BP1 hold the key?

Amr Omer, Sergio Di Marco, Imed Eddine Gallouzi

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Cellular senescence is a double-edged sword that, depending on the context, acts as either a potent tumor protective mechanism or an age-related driver of diseases such as cancer. Our recent findings show that the rasGAP SH3-binding protein 1 (G3BP1) activates the senescent-associated secretory phenotype (SASP) that, in turn, mediates cancer growth/progression.
Original languageEnglish (US)
JournalMolecular and Cellular Oncology
Volume8
Issue number1
DOIs
StatePublished - Jan 1 2021
Externally publishedYes

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