TY - JOUR
T1 - The X Files: “The Mystery of X Chromosome Instability in Alzheimer’s Disease”
AU - Bajic, Vladan P.
AU - Essack, Magbubah
AU - Zivkovic, Lada
AU - Stewart, Alan
AU - Zafirovic, Sonja
AU - Bajic, Vladimir B.
AU - Gojobori, Takashi
AU - Isenovic, Esma
AU - Spremo-Potparevic, Biljana
N1 - KAUST Repository Item: Exported on 2020-10-01
Acknowledged KAUST grant number(s): BAS/1/1606-01-01, FCC/1/1976-17-01, OSR#4129
Acknowledgements: This work is part of the collaboration between the Laboratory of Radiobiology and Molecular Genetics, Vinca Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia and King Abdullah University of Science and Technology (KAUST), Computational Bioscience Research Center (CBRC), Thuwal, Saudi Arabia. This work has been supported by grants No. 173033 (EI) and No. 173034 (VPB) from the Ministry of Education, Science and Technological Development, Republic of Serbia and by the KAUST grant OSR#4129 (to EI and VBB), which also supported SZ and VPB. VBB has been supported by the KAUST Base Research Fund (BAS/1/1606-01-01), while VBB and ME have been supported by KAUST Office of Sponsored Research (OSR) grant no. FCC/1/1976-17-01. TG has been supported by the King Abdullah University of Science and Technology (KAUST) Base Research Fund (BAS/1/1059-01-01).
PY - 2020/1/28
Y1 - 2020/1/28
N2 - Alzheimer’s disease (AD) is a neurodegenerative disease that affects millions of individuals worldwide and can occur relatively early or later in life. It is well known that genetic components, such as the amyloid precursor protein gene on chromosome 21, are fundamental in early-onset AD (EOAD). To date, however, only the apolipoprotein E4 (ApoE4) gene has been proved to be a genetic risk factor for late-onset AD (LOAD). In recent years, despite the hypothesis that many additional unidentified genes are likely to play a role in AD development, it is surprising that additional gene polymorphisms associated with LOAD have failed to come to light. In this review, we examine the role of X chromosome epigenetics and, based upon GWAS studies, the PCDHX11 gene. Furthermore, we explore other genetic risk factors of AD that involve X-chromosome epigenetics.
AB - Alzheimer’s disease (AD) is a neurodegenerative disease that affects millions of individuals worldwide and can occur relatively early or later in life. It is well known that genetic components, such as the amyloid precursor protein gene on chromosome 21, are fundamental in early-onset AD (EOAD). To date, however, only the apolipoprotein E4 (ApoE4) gene has been proved to be a genetic risk factor for late-onset AD (LOAD). In recent years, despite the hypothesis that many additional unidentified genes are likely to play a role in AD development, it is surprising that additional gene polymorphisms associated with LOAD have failed to come to light. In this review, we examine the role of X chromosome epigenetics and, based upon GWAS studies, the PCDHX11 gene. Furthermore, we explore other genetic risk factors of AD that involve X-chromosome epigenetics.
UR - http://hdl.handle.net/10754/661656
UR - https://www.frontiersin.org/article/10.3389/fgene.2019.01368/full
UR - http://www.scopus.com/inward/record.url?scp=85079496526&partnerID=8YFLogxK
U2 - 10.3389/fgene.2019.01368
DO - 10.3389/fgene.2019.01368
M3 - Article
C2 - 32047510
SN - 1664-8021
VL - 10
JO - Frontiers in Genetics
JF - Frontiers in Genetics
ER -