Time-resolved nanoseconds dynamics of ultrasound contrast agent microbubbles manipulated and controlled by optical tweezers

Valeria Garbin*, Dan Cojoc, Enrico Ferrari, Enzo Di Fabrizio, Marlies Overvelde, Michel Versluis, Sander Van Der Meer, Nico De Jong, Detlef Lohse

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Scopus citations


Optical tweezers enable non-destructive, contact-free manipulation of ultrasound contrast agent (UCA) microbubbles, which are used in medical imaging for enhancing the echogenicity of the blood pool and to quantify organ perfusion. The understanding of the fundamental dynamics of ultrasound-driven contrast agent microbubbles is a first step for exploiting their acoustical properties and to develop new diagnostic and therapeutic applications. In this respect, optical tweezers can be used to study UCA microbubbles under controlled and repeatable conditions, by positioning them away from interfaces and from neighboring bubbles. In addition, a high-speed imaging system is required to record the dynamics of UCA microbubbles in ultrasound, as their oscillations occur on the nanoseconds timescale. In this work, we demonstrate the use of an optical tweezers system combined with a high-speed camera capable of 128-frame recordings at up to 25 million frames per second (Mfps), for the study of individual UCA microbubble dynamics as a function of the distance from solid interfaces.

Original languageEnglish (US)
Title of host publicationOptical Trapping and Optical Micromanipulation III
StatePublished - 2006
Externally publishedYes
EventOptical Trapping and Optical Micromanipulation III - San Diego, CA, United States
Duration: Aug 13 2006Aug 17 2006

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
ISSN (Print)0277-786X


OtherOptical Trapping and Optical Micromanipulation III
Country/TerritoryUnited States
CitySan Diego, CA


  • Diffractive optical elements
  • High speed imaging
  • Laguerre-Gaussian beam
  • Low-index particle
  • Microbubble
  • Optical tweezers
  • Optical vortex
  • Ultrasound contras agent

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering


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