TY - JOUR
T1 - TORC1 is a calcium- and cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity
AU - Kovács, Krisztián A.
AU - Steullet, Pascal
AU - Steinmann, Myriam
AU - Do, Kim Q.
AU - Magistretti, Pierre J.
AU - Halfon, Olivier
AU - Cardinaux, Jean René
PY - 2007/3/13
Y1 - 2007/3/13
N2 - A key feature of memory processes is to link different input signals by association and to preserve this coupling at the level of synaptic connections. Late-phase long-term potentiation (L-LTP), a form of synaptic plasticity thought to encode long-term memory, requires gene transcription and protein synthesis. In this study, we report that a recently cloned coactivator of cAMP-response element-binding protein (CREB), called transducer of regulated CREB activity 1 (TORC1), contributes to this process by sensing the coincidence of calcium and cAMP signals in neurons and by converting it into a transcriptional response that leads to the synthesis of factors required for enhanced synaptic transmission. We provide evidence that TORC1 is involved in L-LTP maintenance at the Schaffer collateral-CA1 synapses in the hippocampus.
AB - A key feature of memory processes is to link different input signals by association and to preserve this coupling at the level of synaptic connections. Late-phase long-term potentiation (L-LTP), a form of synaptic plasticity thought to encode long-term memory, requires gene transcription and protein synthesis. In this study, we report that a recently cloned coactivator of cAMP-response element-binding protein (CREB), called transducer of regulated CREB activity 1 (TORC1), contributes to this process by sensing the coincidence of calcium and cAMP signals in neurons and by converting it into a transcriptional response that leads to the synthesis of factors required for enhanced synaptic transmission. We provide evidence that TORC1 is involved in L-LTP maintenance at the Schaffer collateral-CA1 synapses in the hippocampus.
KW - BDNF
KW - Calcineurin
KW - Long-term potentiation
KW - Memory
KW - cAMP-response element-binding protein
UR - http://www.scopus.com/inward/record.url?scp=34248388957&partnerID=8YFLogxK
U2 - 10.1073/pnas.0607524104
DO - 10.1073/pnas.0607524104
M3 - Article
C2 - 17360587
AN - SCOPUS:34248388957
SN - 0027-8424
VL - 104
SP - 4700
EP - 4705
JO - PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
JF - PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
IS - 11
ER -