TY - JOUR
T1 - TP atlas
T2 - Integration and dissemination of advances in Targeted Proteins Research Program (TPRP)-structural biology project phase II in Japan
AU - Iwayanagi, Takao
AU - Miyamoto, Sei
AU - Konno, Takeshi
AU - Mizutani, Hisashi
AU - Hirai, Tomohiro
AU - Shigemoto, Yasumasa
AU - Gojobori, Takashi
AU - Sugawara, Hideaki
N1 - Funding Information:
Structural biology that seeks to describe the 3-dimensional structures of proteins in correlation with their functions not only serves as the basis for life science research, but also plays a vital role in industrial applications as exemplified in drug developments. Several structural biology projects such as Protein Structure Initiative (http://www.sbkb.org/) and Structural Genomics Consortium (http://www.thesgc. org/about/) are pursuing structures of proteins on a genome wide scale in USA and Europe. In Japan, ‘‘National Project on Protein Structural and Functional Analyses’’ (2002–2006, commonly called ‘‘Protein 3000 Project’’) funded by the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan contributed to achieve advances in structural biology and to establish the three dedicated centers for structural biology at SPring-8 (http://www.spring8.or.jp/en/), Photon Factory (http://pf www.kek.jp/index.html), and RIKEN (RIKEN NMR Facility(http://www.ynmr.riken.jp/en/home.html)).
Funding Information:
Protein 3000 Structure Gallery (http://mdbpr4.genes.nig. ac.jp/p3k/index.html.en) is a comprehensive collection of structural data produced from ‘‘Protein 3000 Project’’ (2002–2006) (the preceding project of TPRP) funded by MEXT. The Information Platform team of TPRP produces and maintains the site since one of its missions is to disseminate information on TPRP and its related activities.
PY - 2012/9
Y1 - 2012/9
N2 - The Targeted Proteins Research Program (TPRP) promoted by the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan is the phase II of structural biology project (2007-2011) following the Protein 3000 Project (2002-2006) in Japan. While the phase I Protein 3000 Project put partial emphasis on the construction and maintenance of pipelines for structural analyses, the TPRP is dedicated to revealing the structures and functions of the targeted proteins that have great importance in both basic research and industrial applications. To pursue this objective, 35 Targeted Proteins (TP) Projects selected in the three areas of fundamental biology, medicine and pharmacology, and food and environment are tightly collaborated with 10 Advanced Technology (AT) Projects in the four fields of protein production, structural analyses, chemical library and screening, and information platform. Here, the outlines and achievements of the 35 TP Projects are summarized in the system named TP Atlas. Progress in the diversified areas is described in the modules of Graphical Summary, General Summary, Tabular Summary, and Structure Gallery of the TP Atlas in the standard and unified format. Advances in TP Projects owing to novel technologies stemmed from AT Projects and collaborative research among TP Projects are illustrated as a hallmark of the Program. The TP Atlas can be accessed at http://net.genes.nig.ac.jp/tpatlas/index-e.html .
AB - The Targeted Proteins Research Program (TPRP) promoted by the Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan is the phase II of structural biology project (2007-2011) following the Protein 3000 Project (2002-2006) in Japan. While the phase I Protein 3000 Project put partial emphasis on the construction and maintenance of pipelines for structural analyses, the TPRP is dedicated to revealing the structures and functions of the targeted proteins that have great importance in both basic research and industrial applications. To pursue this objective, 35 Targeted Proteins (TP) Projects selected in the three areas of fundamental biology, medicine and pharmacology, and food and environment are tightly collaborated with 10 Advanced Technology (AT) Projects in the four fields of protein production, structural analyses, chemical library and screening, and information platform. Here, the outlines and achievements of the 35 TP Projects are summarized in the system named TP Atlas. Progress in the diversified areas is described in the modules of Graphical Summary, General Summary, Tabular Summary, and Structure Gallery of the TP Atlas in the standard and unified format. Advances in TP Projects owing to novel technologies stemmed from AT Projects and collaborative research among TP Projects are illustrated as a hallmark of the Program. The TP Atlas can be accessed at http://net.genes.nig.ac.jp/tpatlas/index-e.html .
KW - National project
KW - Protein 3000 Project
KW - Research dissemination
KW - Structural biology
KW - Targeted Proteins Research Program
UR - http://www.scopus.com/inward/record.url?scp=84865524452&partnerID=8YFLogxK
U2 - 10.1007/s10969-012-9139-1
DO - 10.1007/s10969-012-9139-1
M3 - Article
C2 - 22644393
AN - SCOPUS:84865524452
SN - 1345-711X
VL - 13
SP - 145
EP - 154
JO - Journal of Structural and Functional Genomics
JF - Journal of Structural and Functional Genomics
IS - 3
ER -