Transition-metal-free catalytic synthesis of 1,5-diaryl-1,2,3-triazoles

Sen W. Kwok; Joseph R. Fotsing; Rebecca J. Fraser; Valentin O. Rodionov; Valery V. Fokin

doi:10.1021/ol101568d

Transition-metal-free catalytic synthesis of 1,5-diaryl-1,2,3-triazoles

Sen W. Kwok, Joseph R. Fotsing, Rebecca J. Fraser, Valentin O. Rodionov, Valery V. Fokin

Research output: Contribution to journal › Article › peer-review

231 Scopus citations

Abstract

Figure Presented. 1,5-Diarylsubstituted 1,2,3-triazoles are formed in high yield from aryl azides and terminal alkynes in DMSO in the presence of catalytic tetraalkylammonium hydroxide. The reaction is experimentally simple, does not require a transition-metal catalyst, and is not sensitive to atmospheric oxygen and moisture.

Original language	English (US)
Pages (from-to)	4217-4219
Number of pages	3
Journal	Organic Letters
Volume	12
Issue number	19
DOIs	https://doi.org/10.1021/ol101568d
State	Published - Oct 1 2010
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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title = "Transition-metal-free catalytic synthesis of 1,5-diaryl-1,2,3-triazoles",

abstract = "Figure Presented. 1,5-Diarylsubstituted 1,2,3-triazoles are formed in high yield from aryl azides and terminal alkynes in DMSO in the presence of catalytic tetraalkylammonium hydroxide. The reaction is experimentally simple, does not require a transition-metal catalyst, and is not sensitive to atmospheric oxygen and moisture.",

author = "Kwok, {Sen W.} and Fotsing, {Joseph R.} and Fraser, {Rebecca J.} and Rodionov, {Valentin O.} and Fokin, {Valery V.}",

year = "2010",

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doi = "10.1021/ol101568d",

language = "English (US)",

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journal = "Organic Letters",

issn = "1523-7060",

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TY - JOUR

T1 - Transition-metal-free catalytic synthesis of 1,5-diaryl-1,2,3-triazoles

AU - Kwok, Sen W.

AU - Fotsing, Joseph R.

AU - Fraser, Rebecca J.

AU - Rodionov, Valentin O.

AU - Fokin, Valery V.

PY - 2010/10/1

Y1 - 2010/10/1

N2 - Figure Presented. 1,5-Diarylsubstituted 1,2,3-triazoles are formed in high yield from aryl azides and terminal alkynes in DMSO in the presence of catalytic tetraalkylammonium hydroxide. The reaction is experimentally simple, does not require a transition-metal catalyst, and is not sensitive to atmospheric oxygen and moisture.

AB - Figure Presented. 1,5-Diarylsubstituted 1,2,3-triazoles are formed in high yield from aryl azides and terminal alkynes in DMSO in the presence of catalytic tetraalkylammonium hydroxide. The reaction is experimentally simple, does not require a transition-metal catalyst, and is not sensitive to atmospheric oxygen and moisture.

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U2 - 10.1021/ol101568d

DO - 10.1021/ol101568d

M3 - Article

C2 - 20825167

AN - SCOPUS:77957163768

SN - 1523-7060

VL - 12

SP - 4217

EP - 4219

JO - Organic Letters

JF - Organic Letters

IS - 19

ER -

Transition-metal-free catalytic synthesis of 1,5-diaryl-1,2,3-triazoles

Abstract

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