TY - JOUR
T1 - Translational and post-translational regulation of polyamine metabolic enzymes in plants.
AU - Jiménez-Bremont, J F
AU - Chávez-Martínez, A I
AU - Ortega-Amaro, M A
AU - Guerrero-González, M L
AU - Jasso-Robles, F I
AU - Maruri Lopez, Israel
AU - Liu, Ji-Hong
AU - Gill, Sarvajeet Singh
AU - Rodríguez-Kessler, M
N1 - KAUST Repository Item: Exported on 2022-01-27
Acknowledgements: This study was financed by Investigación Ciencia Básica CONACYT-México (2015-256574; 2017-2018-A1-S-25233), Ciencia de Frontera CONACYT-México (2019-1564453), National Key Research and Development Program of China (2018YFD1000302) and the National Natural Science Foundation of China (31772273). We apologize to those colleagues whose relevant work were not cited due to space constraints. We thank to Dr. Michael Frederick Dunn for his critical and grammatical review.
PY - 2021/12/16
Y1 - 2021/12/16
N2 - Polyamines are small organic and basic polycations that perform essential regulatory functions in all living organisms. Fluctuations in polyamine content have been observed to occur during growth, development and under stress conditions, implying that polyamines play pivotal roles in diverse cellular and physiological processes. To achieve polyamine homeostasis, the entire metabolic pathway is subjected to a fine-tuned regulation of its biosynthetic and catabolic genes and enzymes. In this review, we describe and discuss the most important mechanisms implicated in the translational and post-translational regulation of polyamine metabolic enzymes in plants. At the translational level, we emphasize the role of polyamines in the modulation of upstream open reading frame (uORF) activities that control the translation of polyamine biosynthetic and catabolic mRNAs. At the post-translational level, different aspects of the regulation of polyamine metabolic proteins are depicted, such as the proteolytic activation of enzyme precursors, the importance of dimerization in protein stability as well as in protein intracellular localization.
AB - Polyamines are small organic and basic polycations that perform essential regulatory functions in all living organisms. Fluctuations in polyamine content have been observed to occur during growth, development and under stress conditions, implying that polyamines play pivotal roles in diverse cellular and physiological processes. To achieve polyamine homeostasis, the entire metabolic pathway is subjected to a fine-tuned regulation of its biosynthetic and catabolic genes and enzymes. In this review, we describe and discuss the most important mechanisms implicated in the translational and post-translational regulation of polyamine metabolic enzymes in plants. At the translational level, we emphasize the role of polyamines in the modulation of upstream open reading frame (uORF) activities that control the translation of polyamine biosynthetic and catabolic mRNAs. At the post-translational level, different aspects of the regulation of polyamine metabolic proteins are depicted, such as the proteolytic activation of enzyme precursors, the importance of dimerization in protein stability as well as in protein intracellular localization.
UR - http://hdl.handle.net/10754/675152
UR - https://linkinghub.elsevier.com/retrieve/pii/S016816562100300X
UR - http://www.scopus.com/inward/record.url?scp=85121276554&partnerID=8YFLogxK
U2 - 10.1016/j.jbiotec.2021.12.004
DO - 10.1016/j.jbiotec.2021.12.004
M3 - Article
C2 - 34915092
SN - 0168-1656
VL - 344
SP - 1
EP - 10
JO - Journal of Biotechnology
JF - Journal of Biotechnology
ER -