TY - JOUR
T1 - Transposable elements and circular DNAs
AU - Mourier, Tobias
N1 - KAUST Repository Item: Exported on 2020-10-01
PY - 2016/9/26
Y1 - 2016/9/26
N2 - Circular DNAs are extra-chromosomal fragments that become circularized by genomic recombination events. We have recently shown that yeast LTR elements generate circular DNAs through recombination events between their flanking long terminal repeats (LTRs). Similarly, circular DNAs can be generated by recombination between LTRs residing at different genomic loci, in which case the circular DNA will contain the intervening sequence. In yeast, this can result in gene copy number variations when circles contain genes and origins of replication. Here, I speculate on the potential and implications of circular DNAs generated through recombination between human transposable elements.
AB - Circular DNAs are extra-chromosomal fragments that become circularized by genomic recombination events. We have recently shown that yeast LTR elements generate circular DNAs through recombination events between their flanking long terminal repeats (LTRs). Similarly, circular DNAs can be generated by recombination between LTRs residing at different genomic loci, in which case the circular DNA will contain the intervening sequence. In yeast, this can result in gene copy number variations when circles contain genes and origins of replication. Here, I speculate on the potential and implications of circular DNAs generated through recombination between human transposable elements.
UR - http://hdl.handle.net/10754/622823
UR - http://www.tandfonline.com/doi/full/10.1080/2159256X.2016.1240748
U2 - 10.1080/2159256x.2016.1240748
DO - 10.1080/2159256x.2016.1240748
M3 - Article
C2 - 28090380
SN - 2159-256X
VL - 6
SP - e1240748
JO - Mobile Genetic Elements
JF - Mobile Genetic Elements
IS - 6
ER -